Parameter Value
Starting at 10 with two-step titration to 20
Assess efficacy of lixisenatide vs. sitagliptin on composite endpoint of HbA1c and body weight when used as add-on treatment to metformin over 24 wks in obese Type 2 diabetic patients younger than 50
Assess effects of lixisenatide on absolute changes in HbA1c values and body weight
Assess effects of lixisenatide on fasting plasma glucose
Assess effects of lixisenatide on plasma glucose, insulin, C peptide, glucagon, and proinsulin during a 2-hour standardized meal test
Assess effects of lixisenatide on insulin resistance assessed by HOMA-IR
Assess effects of lixisenatide on beta cell function assessed by HOMA-beta
Assess lixisenatide safety and tolerability