WNT Involved in both development and tissue homeostasis. The canonical Wnt pathway involves signal transduction initiated by Wnt ligand binding to Frizzled family receptors leading to the dysregulation of beta-catenin degradation and ultimately, the induction of transcription via TCF/LEF transcription factors by beta-catenin. --NODE_NAME NODE_ID NODE_TYPE PARENT_ID POSX POSY-- SFRP3 EiQGCkYbf2Ue GENE aqCo94T-f2UY 214 113 DKK RpK5JOBLf2U5 FAMILY -1 819 306 TLE1 oLjLH1mCf2T6 GENE z1BS71lif2T2 702 625 TLE4 UjSaC5Phf2T3 GENE z1BS71lif2T2 858 685 SFRP1 LgjBpjM-f2Ux GENE aqCo94T-f2UY 63 147 Groucho z1BS71lif2T2 FAMILY -1 780 655 APC KzWeNNlbf2UJ GENE -1 228 521 TCF7L1 letl9duUf2WR GENE abIO9oDkf2WA 341 691 WIF1 5iL99X9Jf2Tw GENE -1 452 61 TLE2 R0vKN1sif2T9 GENE z1BS71lif2T2 858 625 DKK1 DRSXFgEQf2U9 GENE RpK5JOBLf2U5 739 275 TCF7L2 RPLZ4osLf2Wb GENE abIO9oDkf2WA 499 690 AXIN1 Kq4oChNGf2Vz GENE koQkppv4f2Vq 599 443 WNT Dual Receptor Complex qRabkjW8f2VS COMPLEX -1 458 304 SFRP2 hqXcbX1yf2U1 GENE aqCo94T-f2UY 63 203 LRP5 DK7CkEYCf2Vi GENE qRabkjW8f2VS 536 276 TCF7 pK9uMdhUf2WH GENE abIO9oDkf2WA 422 632 TLE3 mA6zfzOUf2UA GENE z1BS71lif2T2 702 685 Cell proliferation hFWwt8jrf2UV PROCESS -1 135 667 TCF/LEF abIO9oDkf2WA COMPLEX -1 420 661 AXIN koQkppv4f2Vq FAMILY -1 678 443 RNF43 elbyeD9tf2UD GENE -1 144 303 CTNNB1 3GRyWPj8f2UM GENE -1 417 485 DKK2 yYuxYP9Qf2VC GENE RpK5JOBLf2U5 899 275 FZDs jR_K-66Df2VX GENE qRabkjW8f2VS 381 301 DKK4 lRy7Jj0Nf2VN GENE RpK5JOBLf2U5 899 337 SFRP aqCo94T-f2UY FAMILY -1 138 169 WNT ligands wCThVVjSf2Tz GENE -1 452 168 LRP6 nr8aMEmUf2Vd GENE qRabkjW8f2VS 536 332 GSK3B muxig_C-f2UG GENE -1 228 446 SFRP5 B0f2GOAff2Us GENE aqCo94T-f2UY 214 226 AMER1 pAChF0thf2US GENE -1 599 519 SFRP4 QMwh9gC-f2Ul GENE aqCo94T-f2UY 214 170 AXIN2 pD0TMIi_f2V5 GENE koQkppv4f2Vq 758 443 DKK3 wStErGAEf2VH GENE RpK5JOBLf2U5 739 337 --EDGE_ID SOURCE TARGET EDGE_TYPEINTERACTION_PUBMED_ID XWIzsv56f2Wm aqCo94T-f2UY wCThVVjSf2Tz INHIBITS Bps0rTlOf2W1 pAChF0thf2US 3GRyWPj8f2UM INHIBITS Bt39Pfi9f2W- qRabkjW8f2VS muxig_C-f2UG ACTIVATES x3LsoTaTf2Ww elbyeD9tf2UD qRabkjW8f2VS INHIBITS PgNv7XZif2XA muxig_C-f2UG 3GRyWPj8f2UM INHIBITS -u2h2V6ef2XK abIO9oDkf2WA hFWwt8jrf2UV ACTIVATES an6n-VWDf2Wt wCThVVjSf2Tz qRabkjW8f2VS ACTIVATES h4-_HrCRf2W4 qRabkjW8f2VS koQkppv4f2Vq ACTIVATES 3NL_goRgf2W6 koQkppv4f2Vq 3GRyWPj8f2UM INHIBITS -q76c9PDf2Wy RpK5JOBLf2U5 qRabkjW8f2VS INHIBITS h9BN2IKjf2Wr 5iL99X9Jf2Tw wCThVVjSf2Tz INHIBITS rRLoK5NMf2XD KzWeNNlbf2UJ 3GRyWPj8f2UM INHIBITS l7-kESH_f2XH z1BS71lif2T2 abIO9oDkf2WA INHIBITS