TP53

Pathway centered around the regulation of the tumor suppressor TP53, a gene that regulates apoptosis, cell cycle arrest, senescence, and DNA repair.

--NODE_NAME	NODE_ID	NODE_TYPE	PARENT_ID	POSX	POSY--
Cell survival, proliferation	xDGjGXGMfyG3	PROCESS	-1	133	449
CDKN2A	gx_YWb90fyGp	GENE	-1	-23	235
MDM4	sT2W03HDfyGe	GENE	lK7pvMYZfyGU	319	127
DNA replication stress	YvaYsZcufyHH	PROCESS	-1	597	51
RPS6KA3	Iu0kJKKGfyGM	GENE	-1	597	328
MDM2	qv-3H9tXfyGZ	GENE	lK7pvMYZfyGU	149	127
Senescence, apoptosis	Ikv91AlOfyG-	PROCESS	-1	325	448
undefined	lK7pvMYZfyGU	FAMILY	-1	234	127
TP53	ES5FXiJLfyGu	GENE	-1	233	328
Oncogenic stress	HZxSxJBmfyHE	PROCESS	-1	333	222
ATM	c4Ad6ZYBfyGx	GENE	-1	597	130
CHEK2	Jvx4WzdtfyGk	GENE	-1	597	225

--EDGE_ID	SOURCE	TARGET	EDGE_TYPEINTERACTION_PUBMED_ID
8KZq5XsifyHL	ES5FXiJLfyGu	xDGjGXGMfyG3	INHIBITS	
5e5CkdqDfyHg	gx_YWb90fyGp	ES5FXiJLfyGu	INHIBITS	
WAvkWWubfyHO	Jvx4WzdtfyGk	Iu0kJKKGfyGM	ACTIVATES	
wMOYIFFAfyHS	gx_YWb90fyGp	lK7pvMYZfyGU	INHIBITS	
Zd519CgjfyHd	HZxSxJBmfyHE	ES5FXiJLfyGu	ACTIVATES	
lFKJrXsmfyHb	ES5FXiJLfyGu	Ikv91AlOfyG-	ACTIVATES	
geyskuwAfyHV	lK7pvMYZfyGU	ES5FXiJLfyGu	INHIBITS	
t-G0U6EJfyHR	Iu0kJKKGfyGM	ES5FXiJLfyGu	ACTIVATES	
vNvONKmFfyHj	YvaYsZcufyHH	c4Ad6ZYBfyGx	ACTIVATES	
25K5WaLwfyHX	c4Ad6ZYBfyGx	Jvx4WzdtfyGk	ACTIVATES