RTK-RAS A signaling cascade pathway initiated by activation of RTKs followed signal transduction through Ras then Raf and then MEK family members. This cascade leads to the activation of several transcription factors that regulate processes involving cell proliferation and survival. --NODE_NAME NODE_ID NODE_TYPE PARENT_ID POSX POSY-- NRAS QHZo7kkDfrMO GENE b8V1sXZDfrL1 1142 348 ROS1 tNj2tohofrKR GENE 8tMooF5vfrKJ 664 166 KIT gWlRUSfzfrKt GENE 8tMooF5vfrKJ 1142 104 Translation 7CK2REgNfrKF PROCESS -1 881 625 PTPN11 jTtQAhJrfrJx GENE -1 504 348 RAS b8V1sXZDfrL1 FAMILY -1 1063 348 RET yjRzsMVifrKy GENE 8tMooF5vfrKJ 504 166 CBL 0a_o8sXafrJh GENE -1 504 262 Proliferation 3VFXQGLzfrJ- PROCESS -1 559 626 FLT3 IpmlW5vMfrLc GENE 8tMooF5vfrKJ 982 166 NF1 59lXGxKMfrJn GENE -1 1142 262 NTRK2 5SlBGbo1frLr GENE 8tMooF5vfrKJ 1302 166 ERRFI1 -V-9_6fAfrJj GENE -1 664 262 ARAF cBahXkGvfrMn GENE sApg3-IVfrMe 982 429 FGFR3 1EucZO9pfrLJ GENE 8tMooF5vfrKJ 824 104 HRAS BB8hBTZ4frME GENE b8V1sXZDfrL1 982 348 MET _yKldPkzfrKZ GENE 8tMooF5vfrKJ 1142 41 RAF1 Lk9sb9wzfrM5 GENE sApg3-IVfrMe 1302 429 RAC1 zDRSUmjffrJ7 GENE -1 614 511 FGFR1 RFZ2wD4YfrKf GENE 8tMooF5vfrKJ 504 104 MEK 3psJQJmGfrJV FAMILY -1 1062 511 FGFR2 nTecsKLYfrKj GENE 8tMooF5vfrKJ 664 104 KRAS e8tWMLoVfrL9 GENE b8V1sXZDfrL1 824 348 BRAF NM12nD_nfrMx GENE sApg3-IVfrMe 1142 429 ERBB2 C45Adl13frKV GENE 8tMooF5vfrKJ 664 41 ERBB4 Z-e0kCBwfrKN GENE 8tMooF5vfrKJ 982 41 MAPK1 R9ZNAxVRfrJ3 GENE -1 783 511 RAF sApg3-IVfrMe FAMILY -1 1142 429 EGFR 9Psi8emvfrK3 GENE 8tMooF5vfrKJ 504 41 RASA1 ZSZjKexZfrJ0 GENE -1 1301 262 FGFR4 Mfs6mvKHfrKo GENE 8tMooF5vfrKJ 982 104 IGF1R CvsyhyzdfrLQ GENE 8tMooF5vfrKJ 1302 104 ERBB3 rORV55VHfrK9 GENE 8tMooF5vfrKJ 824 41 Cell survival vmWLLGP3frKC PROCESS -1 718 626 SOS1 bdPjTyaDfrJu GENE -1 982 262 RIT1 pTVg5xU2frMW GENE b8V1sXZDfrL1 1302 348 MAP2K2 gqrpYTM0frJa GENE 3psJQJmGfrJV 1142 511 ALK 1o_9LYSFfrLV GENE 8tMooF5vfrKJ 824 166 NTRK1 T6ceghhpfrLj GENE 8tMooF5vfrKJ 1142 166 RTKs 8tMooF5vfrKJ FAMILY -1 903 103 PDGFRA y8PZ8iiyfrLD GENE 8tMooF5vfrKJ 1302 41 MAP2K1 Q2i0HY0HfrJe GENE 3psJQJmGfrJV 982 511 --EDGE_ID SOURCE TARGET EDGE_TYPEINTERACTION_PUBMED_ID Rokn-zgqfrNN -V-9_6fAfrJj 8tMooF5vfrKJ INHIBITS BvZejKrrfrNX 59lXGxKMfrJn b8V1sXZDfrL1 INHIBITS CEWkH2kYfrNa ZSZjKexZfrJ0 b8V1sXZDfrL1 INHIBITS In_EmpIgfrNv R9ZNAxVRfrJ3 7CK2REgNfrKF ACTIVATES NYpLslu-frNh sApg3-IVfrMe 3psJQJmGfrJV ACTIVATES 8OWp0SRTfrNm zDRSUmjffrJ7 R9ZNAxVRfrJ3 ACTIVATES OnjXx-jmfrNk 3psJQJmGfrJV R9ZNAxVRfrJ3 ACTIVATES HPbM8huafrNU bdPjTyaDfrJu b8V1sXZDfrL1 ACTIVATES qtmobl6_frNF 0a_o8sXafrJh 8tMooF5vfrKJ INHIBITS 8EmU4xtSfrNo R9ZNAxVRfrJ3 3VFXQGLzfrJ- ACTIVATES n_C1QGZ2frNr R9ZNAxVRfrJ3 vmWLLGP3frKC ACTIVATES vQrHXLexfrNR 8tMooF5vfrKJ bdPjTyaDfrJu ACTIVATES gs6EgVUcfrNd b8V1sXZDfrL1 sApg3-IVfrMe ACTIVATES