PI3K

A signaling cascade involving PI3K phosphorylation of AKT leading to the activation of the mTORC1 complex. The mTORC1 functions as a metabolic sensor and controls protein abundance by affecting processes involved in protein production and RNA translation leading to changes in cell growth and survival.

--NODE_NAME	NODE_ID	NODE_TYPE	PARENT_ID	POSX	POSY--
AKT3	eWz9lexke0kY	GENE	yEOAK96Ye0j-	752	327
RPTOR	KHzd_YdNe0jd	GENE	JKE-mm1le0jZ	759	730
PIK3CA	BpH76ff7e0iw	GENE	-1	595	176
PIK3R2	5lBs8QfFe0i_	GENE	iK4blWyDe0i1	804	167
RHEB	8eeCwYTqe0jC	GENE	-1	599	619
PIK3R	iK4blWyDe0i1	FAMILY	-1	804	166
AKT	yEOAK96Ye0j-	FAMILY	-1	594	327
mTORC2	MMeMHe4ze0kj	FAMILY	-1	421	730
TSC	3b8rKMrke0jF	FAMILY	-1	596	486
AKT2	9o76blkNe0kR	GENE	yEOAK96Ye0j-	594	327
mTORC1	JKE-mm1le0jZ	FAMILY	-1	678	730
PPP2R1A	HY1OO1uEe0jv	GENE	-1	971	326
PIK3R3	Gy1IflZce0i5	GENE	iK4blWyDe0i1	804	227
PTEN	HL_nLOSce0jV	GENE	-1	594	91
MTOR	_WbyV7oYe0jj	GENE	JKE-mm1le0jZ	597	730
PIK3R1	j_DI0z3Xe0i8	GENE	iK4blWyDe0i1	804	106
Cell growth	_wytH85He0jQ	PROCESS	-1	601	860
INPP4B	2ZOWMzsce0j4	GENE	-1	372	178
TSC1	x2juQzTie0jM	GENE	3b8rKMrke0jF	596	459
TSC2	zs4f_I93e0jJ	GENE	3b8rKMrke0jF	596	513
RICTOR	Dg3B9H1Me0ks	GENE	MMeMHe4ze0kj	421	730
AKT1	TDuOMRUee0kH	GENE	yEOAK96Ye0j-	437	327
STK11	URGrIXe2e0kd	GENE	-1	336	483

--EDGE_ID	SOURCE	TARGET	EDGE_TYPEINTERACTION_PUBMED_ID
an7n5soQe0k8	yEOAK96Ye0j-	3b8rKMrke0jF	INHIBITS	
YeQpbZw0e0lG	3b8rKMrke0jF	8eeCwYTqe0jC	INHIBITS	
wjtVfwEee0lB	JKE-mm1le0jZ	_wytH85He0jQ	ACTIVATES	
6Mr0F0gAe0lD	URGrIXe2e0kd	3b8rKMrke0jF	ACTIVATES	
EigHAJh7e0lI	HL_nLOSce0jV	BpH76ff7e0iw	INHIBITS	
s7B8LZsde0k-	BpH76ff7e0iw	yEOAK96Ye0j-	ACTIVATES	
1T4VmG08e0lL	iK4blWyDe0i1	BpH76ff7e0iw	INHIBITS	
3yNlj0Tge0k2	8eeCwYTqe0jC	JKE-mm1le0jZ	ACTIVATES	
NuGuIugXe0k6	2ZOWMzsce0j4	BpH76ff7e0iw	INHIBITS	
pYhyONrDe0lP	Dg3B9H1Me0ks	URGrIXe2e0kd	ACTIVATES	
h-JnEMgBe0lN	HY1OO1uEe0jv	yEOAK96Ye0j-	INHIBITS