NOTCH Pathway involved in cell-cell communication, cell fate. Cleavage of Notch receptors leads to the displacement of a transcription repressor complex on RBPJ (a transcription factor also known as CSL) accompanied by recruitment of an activation complex (including MAMLs) leads to transcription of Notch target genes. --NODE_NAME NODE_ID NODE_TYPE PARENT_ID POSX POSY-- NRARP Iyt-kiQdVYR4 GENE -1 1392 357 CUL1 ORzx_8_5UAjR GENE -1 861 171 CREBBP hrOQVgOCWtHH GENE amGWWOzfWrg1 1006 344 NCOR2 tRKlqV2HWQET GENE 1WQdsd0RVSHH 919 500 SPEN t3mLgYfBWQD4 GENE 1WQdsd0RVSHH 1078 439 NOTCH3 2YXLvEuJWVnS GENE fLn2ytnZVU-1 386 344 amGWWOzfWrg1 COMPLEX -1 1089 309 CNTN6 8xDiqqMtUlgK GENE -1 153 344 HES-X CCp9TqYNVWpA GENE -1 1392 221 KAT2B W6JlNq1wWtHA GENE amGWWOzfWrg1 1171 274 KDM5A THgZUx73WQED GENE 1WQdsd0RVSHH 1240 439 DNER 8lwlJT8zUt7J GENE -1 386 439 NCOR1 Vh9n-uUkWQDu GENE 1WQdsd0RVSHH 917 440 CLEAVED NOTCH H-nBa6GpUrhI COMPLEX -1 781 316 FBXW7 5nfQJAxjT_z9 GENE -1 630 171 1WQdsd0RVSHH FAMILY -1 1079 469 NOTCH1 VG_45lkLWVm6 GENE fLn2ytnZVU-1 386 274 MALM3 dAIql3LLWtG5 GENE amGWWOzfWrg1 1007 274 NOV fhalsWFrUkbl GENE -1 153 274 JAG2 Ejlh1U2VT-P2 GENE -1 285 171 fLn2ytnZVU-1 COMPLEX -1 472 309 HEY-X 0mJB_ECxVXFr GENE -1 1392 288 PSEN2 Xzuk75kgUufI GENE -1 558 439 EP300 q34LVe78WtHT GENE amGWWOzfWrg1 1170 344 NOTCH2 YBZcjlo4WVnH GENE fLn2ytnZVU-1 558 274 ARRDC1 Qj8O9GJNT_AD GENE -1 454 171 NOTCH4 Qf89YkiEWVne GENE fLn2ytnZVU-1 558 344 Cell growth, apoptosis Nvu3J1djU_IC PROCESS -1 1562 439 --EDGE_ID SOURCE TARGET EDGE_TYPEINTERACTION_PUBMED_ID 3ZGBwutXWvCf 1WQdsd0RVSHH amGWWOzfWrg1 INHIBITS ojk1D4nOWbct Ejlh1U2VT-P2 fLn2ytnZVU-1 ACTIVATES U40tVKQcWjcm Xzuk75kgUufI fLn2ytnZVU-1 ACTIVATES qgZ5w26hWm8v 8xDiqqMtUlgK fLn2ytnZVU-1 INHIBITS xzRJacuuWiP- 5nfQJAxjT_z9 H-nBa6GpUrhI INHIBITS _RaZlGxreARX Iyt-kiQdVYR4 Nvu3J1djU_IC INHIBITS 6YudlCKlWygq amGWWOzfWrg1 CCp9TqYNVWpA ACTIVATES 6YYOMrO7W1Lu amGWWOzfWrg1 Iyt-kiQdVYR4 ACTIVATES y9nj-EHqWlEU fhalsWFrUkbl fLn2ytnZVU-1 INHIBITS QgTnL-0zWfX- 8lwlJT8zUt7J fLn2ytnZVU-1 ACTIVATES YvuJzpCJWoS3 ORzx_8_5UAjR 5nfQJAxjT_z9 ACTIVATES QWoJOCVzW3SR 0mJB_ECxVXFr Nvu3J1djU_IC ACTIVATES 9I6RH1JoWwwW H-nBa6GpUrhI amGWWOzfWrg1 ACTIVATES 4oG8A9OTWz_Z amGWWOzfWrg1 0mJB_ECxVXFr ACTIVATES WZmI2ceJWg0e Qj8O9GJNT_AD fLn2ytnZVU-1 INHIBITS U1KCxbf0W2Wy CCp9TqYNVWpA Nvu3J1djU_IC ACTIVATES