/// <reference types="node" />
import { Subscription } from 'subscription';
import { FormatterFactory } from './formatters';
import { GenerateImageOptions, StructService, CalculateData, type CalculateResult } from "../domain/services";
import { Editor } from './editor';
import { Indigo } from "./indigo";
import { MolfileFormat } from "../domain/serializers";
import { Struct } from "../domain/entities";
import { EventEmitter } from 'events';
import { LogSettings } from "../utilities";
import { ExportImageParams, SupportedImageFormats, SupportedModes, UpdateMonomersLibraryParams } from "./ketcher.types";
declare type SetMoleculeOptions = {
    position?: {
        x: number;
        y: number;
    };
    needZoom?: boolean;
};
export declare class Ketcher {
    #private;
    _id: string;
    logging: LogSettings;
    structService: StructService;
    _indigo: Indigo;
    changeEvent: Subscription;
    libraryUpdateEvent: Subscription;
    get editor(): Editor;
    get eventBus(): EventEmitter;
    constructor(structService: StructService, formatterFactory: FormatterFactory);
    get id(): string;
    get formatterFactory(): FormatterFactory;
    get indigo(): Indigo;
    get settings(): {};
    addEditor(editor: Editor): void;
    setSettings(settings: Record<string, string | boolean>): any;
    getSmiles(isExtended?: boolean): Promise<string>;
    getExtendedSmiles(): Promise<string>;
    getMolfile(molfileFormat?: MolfileFormat): Promise<string>;
    getIdt(): Promise<string>;
    getAxoLabs(): Promise<string>;
    getRxn(molfileFormat?: MolfileFormat): Promise<string>;
    getKet(): Promise<string>;
    getFasta(): Promise<string>;
    getSequence(format?: '1-letter' | '3-letter'): Promise<string>;
    getSmarts(): Promise<string>;
    getCml(): Promise<string>;
    getSdf(molfileFormat?: MolfileFormat): Promise<string>;
    getRdf(molfileFormat?: MolfileFormat): Promise<string>;
    getCDXml(): Promise<string>;
    getCDX(): Promise<string>;
    getInchi(withAuxInfo?: boolean): Promise<string>;
    getInChIKey(): Promise<string>;
    containsReaction(): boolean;
    isQueryStructureSelected(): boolean;
    setMolecule(structStr: string, options?: SetMoleculeOptions): Promise<void | undefined>;
    setHelm(helmStr: string): Promise<void | undefined>;
    addFragment(structStr: string, options?: SetMoleculeOptions): Promise<void | undefined>;
    circularLayoutMonomers(): Promise<void>;
    layout(): Promise<void>;
    calculate(options?: CalculateData): Promise<CalculateResult>;
    /**
     * @param {number} value - in a range [ZoomTool.instance.MINZOOMSCALE, ZoomTool.instance.MAXZOOMSCALE]
     */
    setZoom(value: number): void;
    setMode(mode: SupportedModes): void;
    exportImage(format: SupportedImageFormats, params?: ExportImageParams): void;
    recognize(image: Blob, version?: string): Promise<Struct>;
    generateImage(data: string, options?: GenerateImageOptions): Promise<Blob>;
    reinitializeIndigo(structService: StructService): void;
    sendCustomAction(name: string): void;
    ensureMonomersLibraryDataInKetFormat(rawMonomersData: string | JSON, params?: UpdateMonomersLibraryParams): Promise<string>;
    ensureMonomersLibraryDataInSdfFormat(rawMonomersData: string | JSON, params?: UpdateMonomersLibraryParams): Promise<string>;
    updateMonomersLibrary(rawMonomersData: string | JSON, params?: UpdateMonomersLibraryParams): Promise<void>;
    replaceMonomersLibrary(rawMonomersData: string | JSON, params?: UpdateMonomersLibraryParams): Promise<void>;
    switchToMacromoleculesMode(): void;
    switchToMoleculesMode(): void;
}
export {};