# juice.yaml - 用户配置文件示例
#
# 放置位置（优先级从低到高）：
#   ~/juice.yaml          ← 用户主目录，对所有项目生效
#   <模板文件目录>/juice.yaml ← 仅对当前项目生效（推荐）
#   juice -c <此文件>       ← 命令行指定
#
# 所有配置项均与 CLI 内置默认值深度合并，未填写的字段自动使用内置值。
# 完整默认配置见：<CLI安装目录>/defaults/juice.yaml

# ─── 模板变量（Mustache 语法）────────────────────────────────────────────────
variables:
  overview:
    image: https://pri-cella.oss-ap-southeast-1.aliyuncs.com/edm/202604211419/overview.webp
    title: "Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial"
    link: https://www.nature.com/articles/s41467-026-70340-3
    publicationDate: April 29 2026
    journal: Nature Medicine
    impactFactor: 50.0
    doi: 10.1038/s41591-026-04366-x
    keywords: Immune Thrombocytopenia (ITP), Nicotinamide Mononucleotide (NMN), CD38-NAD<sup>+</sup> Axis

  information:
    isHorizontal: false
    image:
      - https://pri-cella.oss-ap-southeast-1.aliyuncs.com/edm/202604211419/information.webp
    content: "This study identifies the CD38-NAD<sup>+</sup> axis as an immunometabolic checkpoint in ITP. Anti-CD38 antibodies deplete NAD<sup>+</sup>, driving M1 macrophages and FcγRI upregulation, which increases platelet phagocytosis. Restoring NAD<sup>+</sup> via CD38 inhibition or NMN reprograms macrophages to a resting state and blocks platelet destruction without affecting humoral immunity. In 25 refractory ITP patients, low-dose NMN (450 mg bid × 2 weeks) was well tolerated: 20% achieved platelets ≥50×10<sup>9</sup>/L, and 52% maintained response at week 8, with stable immunoglobulin levels. Thus, targeting CD38-NAD<sup>+</sup> metabolism offers a non-antibody-depleting therapeutic strategy."
    link: https://www.procellsystem.com/resources/publications
    buttonText: View More Publications
    summary:

  # ── 产品列表 ────────────────────────────────────────────────────────────────
  # 使用 {{#productLists}}...{{/productLists}} 循环遍历
  # {{#productLists}}{{name}}{{catNo}}{{/productLists}}
  productLists:
    - name: Human NOS2/iNOS(Nitric Oxide Synthase 2, Inducible) ELISA Kit
      catNo: E-EL-H0753
      link: https://www.elabscience.com/p/human-nos2-inos-nitric-oxide-synthase-2-inducible-elisa-kit--e-el-h0753

    - name: Mouse NOS2/iNOS(Nitric Oxide Synthase 2, Inducible) ELISA Kit
      catNo: E-EL-M0696
      link: https://www.elabscience.com/p/mouse-nos2-inos-nitric-oxide-synthase-2-inducible-elisa-kit--e-el-m0696

  recommendedLists:
    - name: DMEM/F12
      catNo: PM150312
      link: https://www.procellsystem.com/p/dmem-f12-pm150312-68139
      image: https://pri-cella.oss-ap-southeast-1.aliyuncs.com/edm/202604211419/PM150312-500mL-cropped.webp

    - name: DMEM (Low glucose)
      catNo: PM150220
      link: https://www.procellsystem.com/p/dmem-low-glucose-pm150220-70471
      image: https://pri-cella.oss-ap-southeast-1.aliyuncs.com/edm/202604211419/PM150220-500mL-cropped.webp

    - name: MEM, with NEAA
      catNo: PM150410
      link: https://www.procellsystem.com/p/mem-with-neaa-pm150410-71162
      image: https://pri-cella.oss-ap-southeast-1.aliyuncs.com/edm/202604211419/PM150410-500mL-cropped.webp