{
    "graph": {
        "nodes": [{
            "metadata": {
                "yloc": 105,
                "xloc": 265
            },
            "id": "p(HGNC:LTA)",
            "label": "p(HGNC:LTA)"
        }, {
            "metadata": {
                "yloc": 30,
                "xloc": 45
            },
            "id": "r(HGNC:IFNG)",
            "label": "r(HGNC:IFNG)"
        }, {
            "metadata": {
                "yloc": 230,
                "xloc": 165
            },
            "id": "bp(GO:\"T-helper 1 type immune response\")",
            "label": "bp(GO:\"T-helper 1 type immune response\")"
        }, {
            "metadata": {
                "yloc": 30,
                "xloc": 265
            },
            "id": "r(HGNC:LTA)",
            "label": "r(HGNC:LTA)"
        }, {
            "metadata": {
                "yloc": 30,
                "xloc": 155
            },
            "id": "r(HGNC:IL2)",
            "label": "r(HGNC:IL2)"
        }, {
            "metadata": {
                "yloc": 30,
                "xloc": 375
            },
            "id": "r(HGNC:LTB)",
            "label": "r(HGNC:LTB)"
        }, {
            "metadata": {
                "yloc": 105,
                "xloc": 45
            },
            "id": "p(HGNC:IFNG)",
            "label": "p(HGNC:IFNG)"
        }, {
            "metadata": {
                "yloc": 105,
                "xloc": 155
            },
            "id": "p(HGNC:IL2)",
            "label": "p(HGNC:IL2)"
        }, {
            "metadata": {
                "yloc": 105,
                "xloc": 375
            },
            "id": "p(HGNC:LTB)",
            "label": "p(HGNC:LTB)"
        }],
        "edges": [{
            "source": "r(HGNC:IL2)",
            "relation": "translatedTo",
            "target": "p(HGNC:IL2)",
            "metadata": {
                "evidences": [{
                    "bel_statement": "r(HGNC:IL2) translatedTo p(HGNC:IL2)",
                    "citation": {
                        "type": "Online Resource",
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                    },
                    "biological_context": {
                        "SpeciesName": "Mouse",
                        "Species": "10090"
                    }
                }, {
                    "bel_statement": "r(HGNC:IL2) translatedTo p(HGNC:IL2)",
                    "citation": {
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                    },
                    "biological_context": {
                        "SpeciesName": "Human",
                        "Species": "9606"
                    }
                }, {
                    "bel_statement": "r(HGNC:IL2) translatedTo p(HGNC:IL2)",
                    "citation": {
                        "type": "Online Resource",
                        "name": "NCBI Entrez Gene",
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                    },
                    "biological_context": {
                        "SpeciesName": "Rat",
                        "Species": "10116"
                    }
                }]
            }
        }, {
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            "relation": "increases",
            "target": "bp(GO:\"T-helper 1 type immune response\")",
            "metadata": {
                "evidences": [{
                    "bel_statement": "p(HGNC:LTA) increases bp(GO:\"T-helper 1 type immune response\")",
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                        "type": "PubMed",
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                        "reference": "15745050"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "IM shows a mainly Th1-type profile, so Th1-type cytokines such as interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and lymphotoxin (LT) are moderately enhanced. "
                }]
            }
        }, {
            "source": "p(HGNC:IFNG)",
            "relation": "increases",
            "target": "bp(GO:\"T-helper 1 type immune response\")",
            "metadata": {
                "evidences": [{
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
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                        "reference": "15745050"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "IM shows a mainly Th1-type profile, so Th1-type cytokines such as interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and lymphotoxin (LT) are moderately enhanced. "
                }, {
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
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                        "reference": "11739273"
                    },
                    "biological_context": {
                        "Cell": "Endothelial Cells",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "IL-12p40, dimerized with the IL-12p35 subunit, triggers synthesis of IFN-, a cytokine that not only directly promotes Th1 responses, but further elevates CD40 levels"
                }, {
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
                        "name": "J Virol 2000 May 74(9) 4429-32",
                        "reference": "10756059"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Mouse",
                        "Species": "10090"
                    },
                    "SummaryText": "Analysis of C57BL/6 mice acutely infected with lymphocytic choriomeningitis virus (LCMV) by using intracellular cytokine staining revealed a high frequency (2 to 10%) of CD4(+) T cells secreting the Th1-associated cytokines interleukin-2 (IL-2), gamma interferon (IFN-gamma), and tumor necrosis factor alpha, with no concomitant increase in the frequency of CD4(+) T cells secreting the Th2-associated cytokines IL-4, IL-5, and IL-10 following stimulation with viral peptides."
                }, {
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
                        "name": "Proc Natl Acad Sci U S A 1999 Mar 16 96(6) 3006-11",
                        "reference": "10077627"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Mouse",
                        "Species": "10090"
                    },
                    "SummaryText": "CyCAP is a widely expressed secreted glycoprotein that modulates the host response to endotoxin gene-targeted CyCAP-deficient mice are more sensitive to the lethal effects of endotoxin in response to endotoxin, CyCAP-deficient mice overproduce interleukin 12 and interferon-gamma systemically and tumor necrosis factor alpha locally, these are proinflammatory molecules that also promote T helper 1 responses"
                }, {
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
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                        "reference": "11057672"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "Th1 cells produce interleukin (IL)-2, interferon-gamma (IFN-gamma) and lymphotoxin-beta, which mediate pro-inflammatory functions critical for the development of cell-mediated immune responses, whereas Th2 cells secrete cytokines such as IL-4, IL-5 and IL-10 that enhance humoral immunity."
                }, {
                    "bel_statement": "p(HGNC:IFNG) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
                        "name": "Science 2001 Jun 8 292(5523) 1907-10",
                        "reference": "11397944"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "TH1 cells express IFN-g and mediate cellular immunity. TH2 cells express IL-4, IL-5, and IL-13 and mediate nonphagocytic immunity."
                }]
            }
        }, {
            "source": "p(HGNC:IL2)",
            "relation": "increases",
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                    },
                    "biological_context": {
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                    },
                    "SummaryText": "IM shows a mainly Th1-type profile, so Th1-type cytokines such as interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and lymphotoxin (LT) are moderately enhanced. "
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                        "type": "PubMed",
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                        "reference": "11057672"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "Th1 cells produce interleukin (IL)-2, interferon-gamma (IFN-gamma) and lymphotoxin-beta, which mediate pro-inflammatory functions critical for the development of cell-mediated immune responses, whereas Th2 cells secrete cytokines such as IL-4, IL-5 and IL-10 that enhance humoral immunity."
                }, {
                    "bel_statement": "p(HGNC:IL2) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
                        "name": "Biochem Biophys Res Commun 1997 Apr 7 233(1) 14-9",
                        "reference": "9144387"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
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                    },
                    "SummaryText": "Furthermore, NO inhibits the proliferation of, and production of interleukin-2 (IL-2) and interferon-gamma by, Th1 but not Th2 cells."
                }, {
                    "bel_statement": "p(HGNC:IL2) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
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                        "reference": "10756059"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Mouse",
                        "Species": "10090"
                    },
                    "SummaryText": "Analysis of C57BL/6 mice acutely infected with lymphocytic choriomeningitis virus (LCMV) by using intracellular cytokine staining revealed a high frequency (2 to 10%) of CD4(+) T cells secreting the Th1-associated cytokines interleukin-2 (IL-2), gamma interferon (IFN-gamma), and tumor necrosis factor alpha, with no concomitant increase in the frequency of CD4(+) T cells secreting the Th2-associated cytokines IL-4, IL-5, and IL-10 following stimulation with viral peptides."
                }]
            }
        }, {
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            "target": "p(HGNC:LTB)",
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                "evidences": [{
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                    },
                    "biological_context": {
                        "SpeciesName": "Rat",
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                    }
                }, {
                    "bel_statement": "r(HGNC:LTB) translatedTo p(HGNC:LTB)",
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                    },
                    "biological_context": {
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                    }
                }, {
                    "bel_statement": "r(HGNC:LTB) translatedTo p(HGNC:LTB)",
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                        "type": "Online Resource",
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                    },
                    "biological_context": {
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                    }
                }]
            }
        }, {
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            "target": "p(HGNC:IFNG)",
            "metadata": {
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                    "bel_statement": "r(HGNC:IFNG) translatedTo p(HGNC:IFNG)",
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                    },
                    "biological_context": {
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                    }
                }, {
                    "bel_statement": "r(HGNC:IFNG) translatedTo p(HGNC:IFNG)",
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                        "type": "Online Resource",
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                    },
                    "biological_context": {
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                    }
                }, {
                    "bel_statement": "r(HGNC:IFNG) translatedTo p(HGNC:IFNG)",
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                    },
                    "biological_context": {
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                    }
                }]
            }
        }, {
            "source": "p(HGNC:LTB)",
            "relation": "increases",
            "target": "bp(GO:\"T-helper 1 type immune response\")",
            "metadata": {
                "evidences": [{
                    "bel_statement": "p(HGNC:LTB) increases bp(GO:\"T-helper 1 type immune response\")",
                    "citation": {
                        "type": "PubMed",
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                        "reference": "11057672"
                    },
                    "biological_context": {
                        "Cell": "Th1 cell",
                        "SpeciesName": "Human",
                        "Species": "9606"
                    },
                    "SummaryText": "Th1 cells produce interleukin (IL)-2, interferon-gamma (IFN-gamma) and lymphotoxin-beta, which mediate pro-inflammatory functions critical for the development of cell-mediated immune responses, whereas Th2 cells secrete cytokines such as IL-4, IL-5 and IL-10 that enhance humoral immunity."
                }]
            }
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            "target": "p(HGNC:LTA)",
            "metadata": {
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                    "bel_statement": "r(HGNC:LTA) translatedTo p(HGNC:LTA)",
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                    },
                    "biological_context": {
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                    },
                    "biological_context": {
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                    }
                }, {
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                    }
                }]
            }
        }],
        "type": "BEL-V1.0",
        "metadata": {
            "customer": "Philip Morris International",
            "speciesName": "Human",
            "description": "The Th1 response model depicts the causal mechanisms that occur following activation of Th1 cells in response to upstream signals, including IFNG, IL2, LTA, and LTB.",
            "modelVersion": "3.0",
            "graphCreatedByEmail": "tthomson@genstruct.com",
            "graphCreatedAt": "1305578028000",
            "graphCreatedBy": "Ty Thomson",
            "graphUpdatedBy": "Ty Thomson",
            "reference_node": "bp(GO:\"T-helper 1 type immune response\")",
            "graphUpdatedByEmail": "tthomson@genstruct.com",
            "graphProject": "System Models Project",
            "graphUpdatedAt": "1305578028000",
            "species": 9606
        }
    }
}