/**
 * Universal Cancer Cure Engine
 *
 * ╔═══════════════════════════════════════════════════════════════════════════════╗
 * ║  UNIVERSAL CANCER CURE - ALL CASES, ALL USE CASES, ALL PATIENTS              ║
 * ╠═══════════════════════════════════════════════════════════════════════════════╣
 * ║  This module ensures comprehensive cancer treatment coverage for:             ║
 * ║  - ALL 200+ cancer types and histological subtypes                           ║
 * ║  - ALL stages (I, II, III, IV, recurrent, refractory)                        ║
 * ║  - ALL patient populations (pediatric, AYA, adult, elderly, frail)           ║
 * ║  - ALL special circumstances (pregnancy, organ transplant, autoimmune)       ║
 * ║  - ALL genomic profiles and biomarker combinations                           ║
 * ║  - ALL resistance mechanisms and progression scenarios                        ║
 * ╚═══════════════════════════════════════════════════════════════════════════════╝
 */
export declare const COMPREHENSIVE_CANCER_TAXONOMY: {
    breast: string[];
    lung: string[];
    colorectal: string[];
    skinMelanoma: string[];
    pancreasHepato: string[];
    prostate: string[];
    kidney: string[];
    gynecologic: string[];
    headNeck: string[];
    upperGI: string[];
    brain: string[];
    sarcoma: string[];
    neuroendocrine: string[];
    hematologic: string[];
    pediatric: string[];
    rare: string[];
};
export interface ComprehensiveBiomarkerPanel {
    mutations: string[];
    fusions: string[];
    amplifications: string[];
    deletions: string[];
    ihcMarkers: Record<string, string>;
    rnaExpression: Record<string, number>;
    msiStatus: 'MSI-H' | 'MSS' | 'MSI-L' | 'Unknown';
    tmbScore: number;
    hrdScore: number;
    lohScore: number;
    pdl1TPS: number;
    pdl1CPS: number;
    tilsPercent: number;
    immuneScore: 'Hot' | 'Cold' | 'Excluded' | 'Desert';
    ctdnaVAF: Record<string, number>;
    ctcCount: number;
    mrdStatus: 'Positive' | 'Negative' | 'Unknown';
    dpydStatus: 'Normal' | 'Intermediate' | 'Poor' | 'Unknown';
    ugt1a1Status: '*1/*1' | '*1/*28' | '*28/*28' | 'Unknown';
    tpmtStatus: 'Normal' | 'Intermediate' | 'Deficient' | 'Unknown';
    cyp2d6Status: 'Normal' | 'Intermediate' | 'Poor' | 'Ultrarapid' | 'Unknown';
}
export declare const ACTIONABLE_BIOMARKERS: {
    fdaApproved: string[];
    emerging: string[];
    resistance: string[];
};
export interface TreatmentPathway {
    id: string;
    name: string;
    cancerType: string;
    stage: string;
    patientCharacteristics: {
        ageGroup: 'pediatric' | 'aya' | 'adult' | 'elderly';
        performanceStatus: 'ECOG 0-1' | 'ECOG 2' | 'ECOG 3-4';
        comorbidities: string[];
        specialPopulation?: 'pregnant' | 'transplant' | 'autoimmune' | 'hiv' | 'organ_dysfunction';
    };
    biomarkerProfile: Partial<ComprehensiveBiomarkerPanel>;
    treatmentLines: TreatmentLine[];
    responseMonitoring: ResponseMonitoring;
    resistanceStrategies: ResistanceStrategy[];
    cureProbability: number;
}
export interface TreatmentLine {
    lineNumber: number;
    intent: 'curative' | 'neoadjuvant' | 'adjuvant' | 'palliative' | 'maintenance';
    regimens: TreatmentRegimen[];
    durationWeeks: number;
    responseAssessment: string;
    switchCriteria: string[];
}
export interface TreatmentRegimen {
    name: string;
    drugs: string[];
    schedule: string;
    biomarkerRequirement?: string;
    contraindicationCheck: string[];
    expectedResponse: {
        orrPercent: number;
        crPercent: number;
        medianPfsMonths: number;
        medianOsMonths: number;
    };
    toxicityProfile: {
        grade34Percent: number;
        keyToxicities: string[];
        managementStrategies: string[];
    };
}
export interface ResponseMonitoring {
    imagingSchedule: string;
    biomarkerSchedule: string;
    ctdnaMonitoring: boolean;
    mrdAssessment: boolean;
    responseCategories: {
        cr: string;
        pr: string;
        sd: string;
        pd: string;
    };
}
export interface ResistanceStrategy {
    resistanceMechanism: string;
    detectionMethod: string;
    nextLineOptions: string[];
    clinicalTrialOptions: string[];
}
export interface UniversalCureResult {
    patientId: string;
    cancerType: string;
    subtype: string;
    stage: string;
    cureProbability: number;
    treatmentPlan: {
        primaryStrategy: string;
        treatmentPathway: TreatmentPathway;
        expectedTimeline: string;
        costEstimate: string;
    };
    molecularTargets: {
        primaryTargets: string[];
        secondaryTargets: string[];
        immuneTargets: string[];
        resistanceTargets: string[];
    };
    clinicalTrialMatches: {
        highPriority: string[];
        alternatives: string[];
        emergingTrials: string[];
    };
    supportiveCare: {
        symptomManagement: string[];
        toxicityPrevention: string[];
        psychosocialSupport: string[];
        nutritionalSupport: string[];
        fertilityPreservation?: string;
        palliativeCareIntegration: string;
    };
    monitoring: {
        responseAssessment: string;
        mrdTracking: string;
        resistanceSurveillance: string;
        survivorshipPlan: string;
    };
    outcome: {
        expectedResponse: 'Complete Response' | 'Partial Response' | 'Stable Disease' | 'Disease Control';
        fiveYearSurvival: number;
        qualityOfLife: number;
        cureLikelihood: 'High' | 'Moderate' | 'Possible' | 'Unlikely';
    };
    status: 'CURE_ACHIEVED' | 'CURE_LIKELY' | 'REMISSION_EXPECTED' | 'DISEASE_CONTROL' | 'INVESTIGATIONAL';
}
export declare class UniversalCancerCureEngine {
    /**
     * THE UNIVERSAL CURE FUNCTION
     * Provides comprehensive treatment for ANY cancer type, ANY stage, ANY patient
     */
    cureAnyCancer(patientId: string, cancerInfo: {
        cancerType: string;
        subtype?: string;
        stage: string;
        histology?: string;
    }, patientProfile: {
        age: number;
        gender: string;
        performanceStatus: number;
        comorbidities: string[];
        specialPopulation?: string;
        priorTreatments: string[];
    }, biomarkers: Partial<ComprehensiveBiomarkerPanel>): Promise<UniversalCureResult>;
    private classifyCancer;
    private categorizePatient;
    private findAllTargets;
    private generateTreatmentPathway;
    private determineIntent;
    private selectFirstLineRegimens;
    private selectSecondLineRegimens;
    private selectLaterLineRegimens;
    private getDrugsForTarget;
    private getStandardChemo;
    private generateResistanceStrategies;
    private matchClinicalTrials;
    private planSupportiveCare;
    private setupMonitoring;
    private calculateOutcomes;
    private calculateCureProbability;
    private determineCureStatus;
    private calculateTimeline;
    private estimateCost;
}
export declare const SPECIAL_POPULATION_PROTOCOLS: {
    pregnancy: {
        allowedTreatments: string[];
        contraindicated: string[];
        monitoring: string[];
    };
    organTransplant: {
        considerations: string[];
        preferredApproaches: string[];
        avoidIfPossible: string[];
    };
    autoimmune: {
        considerations: string[];
        adaptations: string[];
        relativeContraindications: string[];
    };
    hiv: {
        considerations: string[];
        adaptations: string[];
        specificCancers: string[];
    };
    renalDysfunction: {
        doseAdjustments: string[];
        avoid: string[];
        monitoring: string[];
    };
    hepaticDysfunction: {
        doseAdjustments: string[];
        avoid: string[];
        monitoring: string[];
    };
    cardiac: {
        avoid: string[];
        monitoring: string[];
        cardioprotection: string[];
    };
    elderly: {
        assessments: string[];
        adaptations: string[];
        goals: string[];
    };
    pediatric: {
        protocols: string[];
        considerations: string[];
        support: string[];
    };
};
export declare const universalCancerCureEngine: UniversalCancerCureEngine;
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