/**
 * Special Populations Oncology Module
 *
 * ╔═══════════════════════════════════════════════════════════════════════════════╗
 * ║  SPECIAL POPULATIONS - COMPREHENSIVE PROTOCOLS FOR ALL PATIENTS              ║
 * ╠═══════════════════════════════════════════════════════════════════════════════╣
 * ║  This module provides:                                                        ║
 * ║  - Pediatric dosing calculations and protocols                               ║
 * ║  - Geriatric assessment and dose modifications                               ║
 * ║  - Pregnancy-specific management by trimester                                ║
 * ║  - Organ dysfunction dosing adjustments                                      ║
 * ║  - HIV/AIDS oncology protocols                                               ║
 * ║  - Drug interaction safety checking                                          ║
 * ╚═══════════════════════════════════════════════════════════════════════════════╝
 */
export interface PediatricDosingProtocol {
    drug: string;
    indication: string[];
    dosingMethod: 'BSA' | 'Weight' | 'Age-based' | 'Fixed';
    standardDose: string;
    maxDose: string;
    ageAdjustments: AgeAdjustment[];
    organFunctionAdjustments: string[];
    formulations: string[];
    administrationNotes: string[];
    monitoringRequirements: string[];
}
export interface AgeAdjustment {
    ageGroup: 'Neonate (<1 mo)' | 'Infant (1-12 mo)' | 'Toddler (1-3 yr)' | 'Child (3-12 yr)' | 'Adolescent (12-18 yr)';
    adjustment: string;
    rationale: string;
}
export declare function calculateBSA(weight: number, height: number): number;
export declare function calculatePediatricDose(adultDose: number, patientBSA: number, dosingMethod: 'BSA' | 'Weight' | 'Fixed', weight?: number): {
    dose: number;
    unit: string;
    notes: string[];
};
export declare const PEDIATRIC_DOSING_PROTOCOLS: PediatricDosingProtocol[];
export interface GeriatricAssessment {
    domain: string;
    tool: string;
    interpretation: AssessmentInterpretation[];
    treatmentImplications: string[];
}
export interface AssessmentInterpretation {
    score: string;
    category: string;
    meaning: string;
}
export interface GeriatricDosingAdjustment {
    drug: string;
    standardDose: string;
    geriatricConsiderations: string[];
    doseModification: string;
    alternativeAgents?: string[];
    monitoringIntensification: string[];
}
export declare const COMPREHENSIVE_GERIATRIC_ASSESSMENT: GeriatricAssessment[];
export declare const GERIATRIC_DOSING_ADJUSTMENTS: GeriatricDosingAdjustment[];
export interface PregnancyCancerProtocol {
    trimester: 'First' | 'Second' | 'Third';
    generalPrinciples: string[];
    allowedTreatments: TreatmentSafety[];
    contraindicated: string[];
    fetalMonitoring: string[];
    deliveryConsiderations: string[];
}
export interface TreatmentSafety {
    modality: string;
    safety: 'Generally Safe' | 'Use with Caution' | 'Limited Data' | 'Contraindicated';
    evidence: string;
    specificAgents?: string[];
}
export declare const PREGNANCY_CANCER_PROTOCOLS: PregnancyCancerProtocol[];
export interface OrganDysfunctionDosing {
    drug: string;
    renalDosing: RenalDosing[];
    hepaticDosing: HepaticDosing[];
    dialysisGuidance?: string;
}
export interface RenalDosing {
    crclRange: string;
    adjustment: string;
}
export interface HepaticDosing {
    bilirubinRange: string;
    astAltRange: string;
    adjustment: string;
}
export declare const ORGAN_DYSFUNCTION_DOSING: OrganDysfunctionDosing[];
export interface HIVOncologyProtocol {
    cancerType: string;
    artInteractions: ARTInteraction[];
    treatmentModifications: string[];
    prophylaxisRequirements: string[];
    monitoringIntensification: string[];
    prognosticConsiderations: string;
}
export interface ARTInteraction {
    artClass: string;
    interaction: string;
    management: string;
}
export declare const HIV_ONCOLOGY_PROTOCOLS: HIVOncologyProtocol[];
export declare class SpecialPopulationsEngine {
    calculatePediatricDose(drug: string, weight: number, height: number, age: number): {
        dose: string;
        adjustments: string[];
        monitoring: string[];
    };
    performGeriatricAssessment(scores: Record<string, number>): {
        riskCategory: 'Fit' | 'Vulnerable' | 'Frail';
        recommendations: string[];
        treatmentImplications: string[];
    };
    getPregnancyGuidelines(trimester: PregnancyCancerProtocol['trimester']): PregnancyCancerProtocol | undefined;
    getOrganDysfunctionDosing(drug: string, crcl?: number, bilirubin?: number): {
        renalAdjustment: string;
        hepaticAdjustment: string;
    };
    getHIVOncologyProtocol(cancerType: string): HIVOncologyProtocol | undefined;
    getGeriatricDosingAdjustment(drug: string): GeriatricDosingAdjustment | undefined;
}
export declare const specialPopulationsEngine: SpecialPopulationsEngine;
//# sourceMappingURL=specialPopulationsModule.d.ts.map