/**
 * 全球癌症全覆盖框架 (Global Cancer Coverage Framework)
 *
 * ██████╗ ██╗      ██████╗ ██████╗  █████╗ ██╗
 * ██╔════╝ ██║     ██╔═══██╗██╔══██╗██╔══██╗██║
 * ██║  ███╗██║     ██║   ██║██████╔╝███████║██║
 * ██║   ██║██║     ██║   ██║██╔══██╗██╔══██║██║
 * ╚██████╔╝███████╗╚██████╔╝██████╔╝██║  ██║███████╗
 *  ╚═════╝ ╚══════╝ ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝
 *
 * Comprehensive global cancer coverage ensuring:
 * - 所有癌症类型 (All Cancer Types)
 * - 全球治疗指南 (Global Treatment Guidelines)
 * - 特殊人群覆盖 (Special Populations)
 * - 资源有限环境适应 (Resource-Limited Settings)
 * - 支持性护理 (Supportive Care)
 * - 儿科肿瘤全覆盖 (Pediatric Oncology)
 */
export interface GlobalTreatmentGuideline {
    id: string;
    name: string;
    organization: string;
    region: 'Asia' | 'Africa' | 'Europe' | 'Americas' | 'Oceania' | 'Global' | 'WHO';
    country?: string;
    cancerType: string;
    stage: string;
    treatmentModalities: string[];
    adaptationsForResourceLimited: string[];
    localConsiderations: string[];
    efficacyScore: number;
    references: string[];
    languages: string[];
}
export interface SpecialPopulationProtocol {
    id: string;
    name: string;
    population: 'pediatric' | 'adolescent_young_adult' | 'elderly' | 'pregnant' | 'immunocompromised' | 'organ_transplant' | 'rare_syndrome';
    cancerType: string;
    modifications: string[];
    contraindications: string[];
    specialConsiderations: string[];
    monitoringRequirements: string[];
    references: string[];
}
export interface ResourceLimitedAdaptation {
    id: string;
    originalProtocol: string;
    setting: 'low_income' | 'middle_income' | 'rural' | 'conflict_zone' | 'limited_infrastructure';
    adaptedTreatment: string[];
    alternativeDrugs: {
        original: string;
        alternative: string;
        rationale: string;
    }[];
    minimumRequirements: string[];
    expectedOutcome: string;
    references: string[];
}
export interface RareCancerProtocol {
    id: string;
    name: string;
    incidence: string;
    diagnosticCriteria: string[];
    molecularMarkers: string[];
    treatmentOptions: string[];
    referralCenters: string[];
    patientResources: string[];
    clinicalTrials: string[];
}
export interface SupportiveCareProtocol {
    id: string;
    name: string;
    category: 'symptom_management' | 'psychosocial' | 'nutritional' | 'rehabilitation' | 'survivorship' | 'palliative' | 'end_of_life';
    indications: string[];
    interventions: string[];
    medications: string[];
    complementaryApproaches: string[];
    outcomes: string[];
    references: string[];
}
export interface PediatricOncologyProtocol {
    id: string;
    name: string;
    ageGroup: 'infant' | 'child' | 'adolescent';
    cancerType: string;
    riskStratification: string[];
    treatmentPhases: {
        phase: string;
        duration: string;
        agents: string[];
    }[];
    longTermFollowUp: string[];
    fertilityPreservation: string[];
    lateEffectsMonitoring: string[];
    psychosocialSupport: string[];
    references: string[];
}
export declare class GlobalCancerCoverageModule {
    private asianGuidelines;
    private africanGuidelines;
    private latinAmericanGuidelines;
    private middleEasternGuidelines;
    private whoGuidelines;
    private specialPopulationProtocols;
    private resourceLimitedAdaptations;
    private rareCancerProtocols;
    private pediatricProtocols;
    private supportiveCareProtocols;
    getGlobalGuidelines(region?: string, country?: string, cancerType?: string): Promise<GlobalTreatmentGuideline[]>;
    getSpecialPopulationProtocol(population: string, cancerType?: string): Promise<SpecialPopulationProtocol[]>;
    getResourceLimitedAdaptation(setting: string, originalProtocol?: string): Promise<ResourceLimitedAdaptation[]>;
    getRareCancerProtocol(cancerName: string): Promise<RareCancerProtocol | undefined>;
    getAllRareCancerProtocols(): Promise<RareCancerProtocol[]>;
    getPediatricProtocol(cancerType: string, ageGroup?: string): Promise<PediatricOncologyProtocol[]>;
    getAllPediatricProtocols(): Promise<PediatricOncologyProtocol[]>;
    getSupportiveCareProtocol(category: string): Promise<SupportiveCareProtocol[]>;
    getAllSupportiveCareProtocols(): Promise<SupportiveCareProtocol[]>;
    getComprehensiveTreatmentPlan(cancerType: string, stage: string, patientCharacteristics: {
        age: number;
        region: string;
        resourceSetting: 'high_income' | 'middle_income' | 'low_income';
        specialPopulation?: 'pediatric' | 'adolescent_young_adult' | 'elderly' | 'pregnant' | 'immunocompromised';
        comorbidities?: string[];
    }): Promise<{
        primaryProtocol: GlobalTreatmentGuideline | null;
        specialPopulationModifications: SpecialPopulationProtocol | null;
        resourceAdaptations: ResourceLimitedAdaptation | null;
        supportiveCareNeeds: SupportiveCareProtocol[];
        pediatricProtocol: PediatricOncologyProtocol | null;
        rareCancerConsiderations: RareCancerProtocol | null;
        recommendations: string[];
    }>;
    getCoverageStatistics(): {
        totalGlobalGuidelines: number;
        regionsRepresented: string[];
        totalRareCancers: number;
        totalPediatricProtocols: number;
        totalSupportiveCareProtocols: number;
        totalSpecialPopulations: number;
        resourceSettings: string[];
    };
}
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