/**
 * 新兴治疗技术框架 (Emerging Therapeutics Framework)
 *
 * ███████╗███╗   ███╗███████╗██████╗  ██████╗ ██╗███╗   ██╗ ██████╗
 * ██╔════╝████╗ ████║██╔════╝██╔══██╗██╔════╝ ██║████╗  ██║██╔════╝
 * █████╗  ██╔████╔██║█████╗  ██████╔╝██║  ███╗██║██╔██╗ ██║██║  ███╗
 * ██╔══╝  ██║╚██╔╝██║██╔══╝  ██╔══██╗██║   ██║██║██║╚██╗██║██║   ██║
 * ███████╗██║ ╚═╝ ██║███████╗██║  ██║╚██████╔╝██║██║ ╚████║╚██████╔╝
 * ╚══════╝╚═╝     ╚═╝╚══════╝╚═╝  ╚═╝ ╚═════╝ ╚═╝╚═╝  ╚═══╝ ╚═════╝
 *
 * Cutting-edge cancer treatment technologies and novel targets:
 * - 细胞治疗 (Cellular Therapies)
 * - 靶向蛋白降解 (Targeted Protein Degradation)
 * - 基因编辑 (Gene Editing)
 * - 新型抗体技术 (Novel Antibody Technologies)
 * - 纳米医学 (Nanomedicine)
 * - 人工智能药物发现 (AI-Driven Drug Discovery)
 */
export interface EmergingTherapy {
    id: string;
    name: string;
    category: 'cellular' | 'small_molecule' | 'antibody' | 'nucleic_acid' | 'gene_therapy' | 'radiation' | 'other';
    mechanism: string;
    targets: string[];
    cancerTypes: string[];
    developmentStage: 'preclinical' | 'phase_1' | 'phase_2' | 'phase_3' | 'approved' | 'breakthrough_therapy';
    keyTrials: string[];
    advantages: string[];
    challenges: string[];
    estimatedTimeline: string;
    companies: string[];
    references: string[];
}
export interface NovelTarget {
    gene: string;
    protein: string;
    pathway: string;
    targetType: 'oncogene' | 'tumor_suppressor' | 'synthetic_lethality' | 'immune' | 'metabolic' | 'epigenetic' | 'other';
    druggability: 'high' | 'medium' | 'low' | 'undruggable_becoming_druggable';
    cancerTypes: string[];
    approachesInDevelopment: string[];
    leadCompounds: {
        name: string;
        stage: string;
        company: string;
    }[];
    rationale: string;
    references: string[];
}
export interface NextGenCellularTherapy {
    id: string;
    name: string;
    type: 'car_t' | 'car_nk' | 'til' | 'tcr_t' | 'car_m' | 'ipsc_derived' | 'gamma_delta' | 'nkt';
    target: string;
    generation: string;
    modifications: string[];
    cancerTypes: string[];
    advantages: string[];
    clinicalStatus: string;
    keyTrials: string[];
    manufacturers: string[];
}
export interface ProteinDegrader {
    id: string;
    name: string;
    type: 'protac' | 'molecular_glue' | 'lysosome_targeting' | 'autophagy';
    target: string;
    e3Ligase: string;
    linker: string;
    cancerTypes: string[];
    status: string;
    advantages: string[];
    company: string;
    references: string[];
}
export interface RadiopharmaceuticalTherapy {
    id: string;
    name: string;
    radioisotope: string;
    halfLife: string;
    emissionType: 'beta' | 'alpha' | 'auger';
    targetingMoiety: string;
    target: string;
    cancerTypes: string[];
    approvalStatus: string;
    keyTrials: string[];
    advantages: string[];
    sideEffects: string[];
}
export interface AIDiscoveredDrug {
    id: string;
    name: string;
    aiPlatform: string;
    discoveryMethod: string;
    target: string;
    indication: string;
    developmentStage: string;
    company: string;
    timeFromDiscoveryToClinic: string;
    novelty: string;
}
export declare class EmergingTherapeuticsModule {
    private nextGenCellular;
    private proteinDegraders;
    private radiopharmaceuticals;
    private novelAntibodyTech;
    private nucleicAcidTherapies;
    private novelTargets;
    private aiDiscoveredDrugs;
    getNextGenCellularTherapies(type?: string): Promise<NextGenCellularTherapy[]>;
    getProteinDegraders(targetType?: string): Promise<ProteinDegrader[]>;
    getRadiopharmaceuticals(emissionType?: string): Promise<RadiopharmaceuticalTherapy[]>;
    getNovelAntibodyTech(): Promise<EmergingTherapy[]>;
    getNucleicAcidTherapies(): Promise<EmergingTherapy[]>;
    getNovelTargets(druggability?: string): Promise<NovelTarget[]>;
    getAIDiscoveredDrugs(): Promise<AIDiscoveredDrug[]>;
    getAllEmergingTherapies(): Promise<{
        cellularTherapies: NextGenCellularTherapy[];
        proteinDegraders: ProteinDegrader[];
        radiopharmaceuticals: RadiopharmaceuticalTherapy[];
        novelAntibodies: EmergingTherapy[];
        nucleicAcidTherapies: EmergingTherapy[];
        novelTargets: NovelTarget[];
        aiDiscoveredDrugs: AIDiscoveredDrug[];
    }>;
    searchEmergingTherapiesForCancer(cancerType: string): Promise<{
        cellular: NextGenCellularTherapy[];
        degraders: ProteinDegrader[];
        radiopharmaceuticals: RadiopharmaceuticalTherapy[];
        antibodies: EmergingTherapy[];
        nucleicAcid: EmergingTherapy[];
        targets: NovelTarget[];
    }>;
    getStatistics(): {
        totalCellularTherapies: number;
        totalProteinDegraders: number;
        totalRadiopharmaceuticals: number;
        totalNovelAntibodies: number;
        totalNucleicAcid: number;
        totalNovelTargets: number;
        totalAIDrugs: number;
        breakdownByStage: Record<string, number>;
    };
}
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