/**
 * Emergency Oncology and Oncologic Emergencies Protocols
 *
 * ╔═══════════════════════════════════════════════════════════════════════════════╗
 * ║  EMERGENCY ONCOLOGY - LIFE-SAVING INTERVENTIONS FOR CANCER EMERGENCIES       ║
 * ╠═══════════════════════════════════════════════════════════════════════════════╣
 * ║  This module provides protocols for:                                          ║
 * ║  - Structural emergencies (SVC syndrome, spinal cord compression, etc.)      ║
 * ║  - Metabolic emergencies (TLS, hypercalcemia, SIADH, etc.)                   ║
 * ║  - Treatment-related emergencies (febrile neutropenia, CRS, irAEs)           ║
 * ║  - Extravasation and infusion reactions                                       ║
 * ║  - Hemorrhagic and thrombotic emergencies                                    ║
 * ║  - Rapid-onset symptoms requiring immediate intervention                      ║
 * ╚═══════════════════════════════════════════════════════════════════════════════╝
 */
export interface OncologicEmergency {
    id: string;
    name: string;
    category: EmergencyCategory;
    urgency: 'Immediate' | 'Urgent' | 'Semi-urgent';
    timeToIntervention: string;
    recognition: RecognitionCriteria;
    initialManagement: EmergencyManagement[];
    definitiveManagement: DefinitiveManagement[];
    monitoring: MonitoringProtocol;
    outcomes: OutcomeExpectations;
    preventionStrategies: string[];
}
export type EmergencyCategory = 'Structural' | 'Metabolic' | 'Hematologic' | 'Treatment-Related' | 'Infectious' | 'Neurologic' | 'Cardiovascular' | 'Respiratory';
export interface RecognitionCriteria {
    symptoms: string[];
    signs: string[];
    diagnosticCriteria: string[];
    labFindings?: string[];
    imagingFindings?: string[];
    riskFactors: string[];
}
export interface EmergencyManagement {
    step: number;
    action: string;
    timing: string;
    details: string;
    medications?: MedicationOrder[];
    contraindications?: string[];
}
export interface MedicationOrder {
    drug: string;
    dose: string;
    route: string;
    frequency: string;
    duration: string;
    monitoring?: string;
}
export interface DefinitiveManagement {
    intervention: string;
    indication: string;
    timing: string;
    expectedOutcome: string;
    alternatives?: string[];
}
export interface MonitoringProtocol {
    parameters: string[];
    frequency: string;
    escalationCriteria: string[];
    deescalationCriteria: string[];
}
export interface OutcomeExpectations {
    withTreatment: string;
    withoutTreatment: string;
    longTermPrognosis: string;
}
export declare const STRUCTURAL_EMERGENCIES: OncologicEmergency[];
export declare const METABOLIC_EMERGENCIES: OncologicEmergency[];
export declare const TREATMENT_RELATED_EMERGENCIES: OncologicEmergency[];
export declare const HEMATOLOGIC_EMERGENCIES: OncologicEmergency[];
export declare class EmergencyOncologyEngine {
    private emergencies;
    constructor();
    private initializeEmergencies;
    getEmergency(id: string): OncologicEmergency | undefined;
    getEmergenciesByCategory(category: EmergencyCategory): OncologicEmergency[];
    getEmergenciesByUrgency(urgency: 'Immediate' | 'Urgent' | 'Semi-urgent'): OncologicEmergency[];
    identifyPotentialEmergency(symptoms: string[], labValues?: Record<string, number>): OncologicEmergency[];
    generateEmergencyProtocol(emergencyId: string, patientFactors?: {
        weight?: number;
        renalFunction?: string;
        allergies?: string[];
    }): {
        emergency: OncologicEmergency;
        prioritizedSteps: EmergencyManagement[];
        contraindicatedSteps: EmergencyManagement[];
        criticalTimepoints: string[];
    } | undefined;
    getAllEmergencies(): OncologicEmergency[];
}
export declare const emergencyOncologyEngine: EmergencyOncologyEngine;
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