/**
 * 癌症治愈验证框架 (Cancer Cure Validation Framework)
 *
 * ██╗   ██╗ █████╗ ██╗     ██╗██████╗  █████╗ ████████╗███████╗
 * ██║   ██║██╔══██╗██║     ██║██╔══██╗██╔══██╗╚══██╔══╝██╔════╝
 * ██║   ██║███████║██║     ██║██║  ██║███████║   ██║   █████╗
 * ╚██╗ ██╔╝██╔══██║██║     ██║██║  ██║██╔══██║   ██║   ██╔══╝
 *  ╚████╔╝ ██║  ██║███████╗██║██████╔╝██║  ██║   ██║   ███████╗
 *   ╚═══╝  ╚═╝  ╚═╝╚══════╝╚═╝╚═════╝ ╚═╝  ╚═╝   ╚═╝   ╚══════╝
 *
 * Comprehensive validation ensuring:
 * - 完整性验证 (Coverage Completeness)
 * - 治疗效果验证 (Treatment Efficacy Validation)
 * - 生存率监测 (Survival Monitoring)
 * - 治愈认证 (Cure Certification)
 * - 复发监测 (Recurrence Surveillance)
 */
export interface CancerCoverageValidation {
    cancerType: string;
    icd10Code: string;
    icdoMorphology: string;
    hasTreatmentProtocol: boolean;
    hasGlobalGuidelines: boolean;
    hasResourceLimitedAdaptation: boolean;
    hasPediatricProtocol: boolean;
    hasEmergingTherapy: boolean;
    hasSupportiveCare: boolean;
    coverageScore: number;
    gaps: string[];
    recommendations: string[];
}
export interface TreatmentOutcomeValidation {
    patientId: string;
    cancerType: string;
    stage: string;
    treatmentProtocol: string;
    startDate: Date;
    currentStatus: 'active_treatment' | 'response' | 'stable' | 'progression' | 'remission' | 'cure_pending' | 'cured';
    responseAssessment: {
        method: 'RECIST' | 'iRECIST' | 'RANO' | 'Lugano' | 'IMWG' | 'Other';
        result: 'CR' | 'PR' | 'SD' | 'PD' | 'NE';
        date: Date;
    };
    biomarkerResponse?: {
        marker: string;
        baseline: number;
        current: number;
        percentChange: number;
    }[];
    molecularResponse?: {
        mrdStatus: 'positive' | 'negative' | 'not_assessed';
        ctdnaStatus?: 'detected' | 'not_detected' | 'not_assessed';
        sensitivity: string;
    };
    nextAssessment: Date;
}
export interface CureCriteria {
    cancerType: string;
    definition: string;
    timeRequirement: string;
    biomarkerRequirements: string[];
    imagingRequirements: string[];
    clinicalRequirements: string[];
    surveillanceProtocol: string[];
    lateEffectsMonitoring: string[];
}
export interface CureVerification {
    patientId: string;
    cancerType: string;
    diagnosisDate: Date;
    treatmentCompletionDate: Date;
    currentDate: Date;
    timeSinceCompletion: string;
    cureStatus: 'pending' | 'conditional' | 'verified' | 'not_applicable';
    criteriaMetStatus: {
        criterion: string;
        met: boolean;
        evidence: string;
    }[];
    overallConfidence: number;
    nextVerificationDate: Date;
    surveillanceSchedule: {
        assessment: string;
        date: Date;
    }[];
}
export interface ComprehensiveCoverageReport {
    generatedAt: Date;
    totalCancerTypes: number;
    coveredCancerTypes: number;
    coveragePercentage: number;
    byCategory: {
        solidTumors: {
            total: number;
            covered: number;
        };
        hematologic: {
            total: number;
            covered: number;
        };
        pediatric: {
            total: number;
            covered: number;
        };
        rare: {
            total: number;
            covered: number;
        };
    };
    byRegion: {
        nccn: number;
        esmo: number;
        asian: number;
        african: number;
        latinAmerican: number;
        who: number;
    };
    gaps: CancerCoverageValidation[];
    recommendations: string[];
}
export declare const COMPLETE_CANCER_TAXONOMY: {
    solidTumors: {
        headAndNeck: string[];
        thoracic: string[];
        breast: string[];
        giUpper: string[];
        giLower: string[];
        hepatobiliary: string[];
        pancreas: string[];
        genitourinary: string[];
        gynecologic: string[];
        skin: string[];
        cns: string[];
        bone: string[];
        softTissue: string[];
        neuroendocrine: string[];
        rare: string[];
    };
    hematologic: {
        leukemia: string[];
        lymphoma: string[];
        plasmaCell: string[];
        mpn: string[];
        mds: string[];
    };
    pediatric: {
        solid: string[];
        cns: string[];
        hematologic: string[];
    };
};
export declare const CURE_CRITERIA_DATABASE: CureCriteria[];
export declare class CureValidationFramework {
    /**
     * Validate comprehensive cancer coverage
     */
    validateCoverageCompleteness(): Promise<ComprehensiveCoverageReport>;
    /**
     * Verify patient cure status
     */
    verifyCureStatus(patientId: string, cancerType: string, treatmentHistory: TreatmentOutcomeValidation): Promise<CureVerification>;
    /**
     * Generate coverage validation for a specific cancer type
     */
    validateCancerCoverage(cancerType: string): Promise<CancerCoverageValidation>;
    /**
     * Get all cancer types from taxonomy
     */
    private getAllCancerTypes;
    private assessCoveredTypes;
    private calculateCategoryBreakdown;
    private calculateRegionalBreakdown;
    private generateCoverageRecommendations;
    private calculateTimeSince;
    private evaluateCriteria;
    private calculateCureConfidence;
    private determineCureStatus;
    private calculateNextVerification;
    private generateSurveillanceSchedule;
    private generateGenericCureVerification;
    private calculateCoverageScore;
    private getICD10Code;
    private getICDOMorphology;
    /**
     * Get coverage statistics summary
     */
    getCoverageStatistics(): {
        totalCancerTypesInTaxonomy: number;
        solidTumorCategories: number;
        hematologicCategories: number;
        pediatricCategories: number;
        cureCriteriaDefined: number;
    };
}
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