/**
 * Clinical Trial Matching Engine
 *
 * ╔═══════════════════════════════════════════════════════════════════════════════╗
 * ║  CLINICAL TRIAL MATCHING - CONNECTING PATIENTS TO NOVEL THERAPIES            ║
 * ╠═══════════════════════════════════════════════════════════════════════════════╣
 * ║  This module provides:                                                        ║
 * ║  - Biomarker-to-trial mapping                                                ║
 * ║  - Eligibility criteria assessment                                           ║
 * ║  - Trial phase and mechanism matching                                        ║
 * ║  - Geographic and logistical feasibility                                     ║
 * ║  - Basket, umbrella, and platform trial navigation                           ║
 * ╚═══════════════════════════════════════════════════════════════════════════════╝
 */
export interface ClinicalTrial {
    nctId: string;
    title: string;
    phase: TrialPhase;
    status: TrialStatus;
    trialType: TrialType;
    sponsor: string;
    conditions: string[];
    interventions: TrialIntervention[];
    eligibilityCriteria: EligibilityCriteria;
    locations: TrialLocation[];
    biomarkerRequirements: BiomarkerCriterion[];
    primaryEndpoint: string;
    estimatedEnrollment: number;
    studyStartDate: string;
    estimatedCompletionDate: string;
}
export type TrialPhase = 'Early Phase 1' | 'Phase 1' | 'Phase 1/2' | 'Phase 2' | 'Phase 2/3' | 'Phase 3' | 'Phase 4';
export type TrialStatus = 'Recruiting' | 'Active, not recruiting' | 'Enrolling by invitation' | 'Not yet recruiting' | 'Completed' | 'Suspended' | 'Terminated' | 'Withdrawn';
export type TrialType = 'Interventional' | 'Basket' | 'Umbrella' | 'Platform' | 'Expanded Access';
export interface TrialIntervention {
    type: 'Drug' | 'Biological' | 'Device' | 'Radiation' | 'Procedure' | 'Combination';
    name: string;
    mechanism: string;
    targetedPathway?: string;
    novelty: 'First-in-class' | 'Next-generation' | 'Combination' | 'New indication';
}
export interface EligibilityCriteria {
    ageRange: {
        min: number;
        max: number;
    };
    gender: 'All' | 'Male' | 'Female';
    performanceStatus: {
        scale: 'ECOG' | 'Karnofsky';
        maxValue: number;
    };
    priorTherapyRequirements: PriorTherapyRequirement[];
    organFunctionRequirements: OrganFunctionRequirement[];
    exclusionCriteria: string[];
    inclusionCriteria: string[];
}
export interface PriorTherapyRequirement {
    requirement: 'Required' | 'Allowed' | 'Excluded';
    therapyType: string;
    details: string;
}
export interface OrganFunctionRequirement {
    organ: string;
    parameter: string;
    requirement: string;
}
export interface TrialLocation {
    facility: string;
    city: string;
    state: string;
    country: string;
    status: 'Recruiting' | 'Not yet recruiting' | 'Completed';
    contactName?: string;
    contactPhone?: string;
    contactEmail?: string;
}
export interface BiomarkerCriterion {
    biomarker: string;
    requirement: 'Required' | 'Preferred' | 'Excluded';
    testMethod: string[];
    details?: string;
}
export interface PatientTrialProfile {
    cancerType: string;
    histology: string;
    stage: string;
    biomarkers: PatientBiomarker[];
    priorTherapies: string[];
    currentLine: number;
    age: number;
    performanceStatus: number;
    organFunction: OrganFunctionStatus;
    location: {
        country: string;
        state?: string;
        city?: string;
    };
    willingToTravel: boolean;
    maxTravelDistance?: number;
    preferences: TrialPreferences;
}
export interface PatientBiomarker {
    name: string;
    status: 'Positive' | 'Negative' | 'Unknown';
    value?: string | number;
    method?: string;
}
export interface OrganFunctionStatus {
    renalFunction: 'Normal' | 'Mild impairment' | 'Moderate impairment' | 'Severe impairment';
    hepaticFunction: 'Normal' | 'Mild impairment' | 'Moderate impairment' | 'Severe impairment';
    cardiacFunction: 'Normal' | 'Reduced' | 'Severely reduced';
    bonemarrowFunction: 'Normal' | 'Reduced';
}
export interface TrialPreferences {
    preferredPhases: TrialPhase[];
    acceptPlaceboArm: boolean;
    preferLocalTrials: boolean;
    interestedMechanisms: string[];
}
export interface TrialMatch {
    trial: ClinicalTrial;
    matchScore: number;
    matchDetails: MatchDetail[];
    eligibilityStatus: 'Likely Eligible' | 'Possibly Eligible' | 'Likely Ineligible' | 'Need More Info';
    barriers: string[];
    nextSteps: string[];
}
export interface MatchDetail {
    criterion: string;
    status: 'Met' | 'Not Met' | 'Partial' | 'Unknown';
    explanation: string;
}
export declare const TRIAL_DATABASE: ClinicalTrial[];
export declare class ClinicalTrialMatchingEngine {
    private trials;
    findMatchingTrials(patient: PatientTrialProfile): TrialMatch[];
    private evaluateTrialMatch;
    findTrialsByBiomarker(biomarker: string): ClinicalTrial[];
    findTrialsByMechanism(mechanism: string): ClinicalTrial[];
    findBasketTrials(): ClinicalTrial[];
    findPediatricTrials(): ClinicalTrial[];
    getTrialById(nctId: string): ClinicalTrial | undefined;
    generateTrialSearchStrategy(patient: PatientTrialProfile): {
        searchTerms: string[];
        recommendedDatabases: string[];
        searchTips: string[];
    };
}
export declare const clinicalTrialMatchingEngine: ClinicalTrialMatchingEngine;
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