/**
 * 癌症治疗能力框架 (Cancer Treatment Capability Framework)
 *
 * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
 * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
 * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
 * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
 * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
 *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
 *
 * AI-powered cancer treatment capability module implementing:
 * - 个性化治疗计划 (Personalized Treatment Planning)
 * - 药物发现与设计 (Drug Discovery & Design)
 * - 免疫治疗优化 (Immunotherapy Optimization)
 * - CAR-T细胞疗法 (CAR-T Cell Therapy)
 * - 组合疗法优化 (Combination Therapy Optimization)
 * - 临床试验管理 (Clinical Trial Management)
 * - 患者护理协调 (Patient Care Coordination)
 * - 医疗系统集成 (Medical System Integration)
 *
 * All operations require proper medical authorization and compliance.
 */
export type CancerTreatmentOperationType = 'diagnosis_assessment' | 'treatment_planning' | 'drug_design' | 'clinical_trial' | 'patient_monitoring' | 'quality_of_life' | 'followup_care' | 'immunotherapy' | 'car_t_therapy' | 'combination_optimization' | 'cure_cancer';
export interface CancerPatient {
    id: string;
    type: 'patient' | 'clinical_trial_participant' | 'research_subject';
    identifier: string;
    demographics?: {
        age: number;
        gender: string;
        ethnicity?: string;
    };
    medicalHistory?: Record<string, any>;
    genomics?: {
        mutations: string[];
        biomarkers: string[];
        expressionProfiles?: Record<string, number>;
    };
}
export interface CancerTreatmentOperation {
    id: string;
    type: CancerTreatmentOperationType;
    patient: CancerPatient;
    parameters: Record<string, any>;
    authorization: string;
    timestamp: Date;
}
export interface CancerTreatmentResult {
    operationId: string;
    success: boolean;
    outcome: string;
    recommendations: string[];
    nextSteps: string[];
    timestamp: Date;
}
export interface TreatmentProtocol {
    id: string;
    name: string;
    organization: 'NCCN' | 'ESMO' | 'ASCO' | 'WHO' | 'FDA' | 'Other';
    cancerType: string;
    stage: string;
    treatmentModalities: string[];
    efficacyScore: number;
    sideEffectProfile: string[];
    references: string[];
}
export interface DrugTarget {
    gene: string;
    protein: string;
    pathway: string;
    cancerTypes: string[];
    approvedDrugs: string[];
    mechanismOfAction: string;
    evidenceLevel: 'FDA-Approved' | 'Phase III' | 'Phase II' | 'Phase I' | 'Preclinical';
    biomarker?: string;
    resistanceMechanisms?: string[];
}
export interface ImmunotherapyProtocol {
    id: string;
    name: string;
    type: 'checkpoint_inhibitor' | 'car_t' | 'cancer_vaccine' | 'cytokine_therapy' | 'oncolytic_virus';
    targets: string[];
    drugs: string[];
    cancerTypes: string[];
    responseRate: number;
    durableResponseRate: number;
    biomarkers: string[];
}
export interface CombinationTherapy {
    id: string;
    name: string;
    components: string[];
    synergisticEffect: number;
    cancerTypes: string[];
    clinicalEvidence: string;
}
export interface CancerCureResult {
    patientId: string;
    cancerType: string;
    stage: string;
    cureStrategy: string;
    treatments: {
        primary: string;
        secondary: string[];
        supportive: string[];
    };
    drugTargets: DrugTarget[];
    immunotherapy?: ImmunotherapyProtocol;
    combinationTherapy?: CombinationTherapy;
    projectedOutcome: {
        responseRate: number;
        fiveYearSurvival: number;
        qualityOfLife: number;
        cureConfidence: number;
    };
    timeline: {
        phase: string;
        duration: string;
        activities: string[];
    }[];
    breakthroughs: string[];
    status: 'CURED' | 'IN_REMISSION' | 'RESPONDING' | 'STABLE';
}
export declare class CancerTreatmentCapabilityModule {
    private drugTargetDatabase;
    private immunotherapyProtocols;
    private combinationTherapies;
    private treatmentProtocols;
    constructor();
    get metadata(): {
        id: string;
        name: string;
        description: string;
        version: string;
        category: string;
        tags: string[];
    };
    analyzePatient(patientId: string, includeGenomics: boolean): Promise<any>;
    designTreatmentPlan(patientId: string, protocolId?: string): Promise<any>;
    discoverDrugTargets(cancerType: string, targetGene?: string): Promise<any>;
    cureCancer(patientId: string, cancerType: string, stage: string, genomicProfile?: {
        mutations?: string[];
        biomarkers?: string[];
        msiStatus?: 'MSI-H' | 'MSS';
        tmbLevel?: 'High' | 'Low';
        pdl1Expression?: number;
        hrdStatus?: boolean;
    }): Promise<CancerCureResult>;
    private normalizeCancerType;
    private findActionableTargets;
    private selectImmunotherapy;
    private optimizeCombination;
    private matchProtocol;
    private calculateOutcomes;
    private generateTimeline;
    private identifyBreakthroughs;
    private determineCureStrategy;
    private selectPrimaryTreatment;
    private selectSecondaryTreatments;
    listTreatmentProtocols(): Promise<TreatmentProtocol[]>;
    listDrugTargets(): Promise<DrugTarget[]>;
    listImmunotherapyProtocols(): Promise<ImmunotherapyProtocol[]>;
    listCombinationTherapies(): Promise<CombinationTherapy[]>;
    addTreatmentProtocol(protocol: TreatmentProtocol): Promise<void>;
    executeCommand(command: string, params: any): Promise<any>;
}
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