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<h1 class="title toc-ignore">Enrichment results of gout</h1>
<h4 class="author"><em>Xiang Zhu</em></h4>
<h4 class="date"><em>2017-04-12</em></h4>
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<p><strong>Last updated:</strong> 2018-10-05</p>
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<div id="input-data" class="section level2">
<h2>Input data</h2>
<p>Results below were generated from the GWAS summary statistics published in the paper <a href="https://www.ncbi.nlm.nih.gov/pubmed/23263486">“Genome-Wide Association Analyses Identify 18 New Loci Associated with Serum Urate Concentrations” (<em>Nature Genetics</em>, 2013)</a>. The summary data file is available at <a href="http://metabolomics.helmholtz-muenchen.de/gugc" class="uri">http://metabolomics.helmholtz-muenchen.de/gugc</a>.</p>
</div>
<div id="analysis-results" class="section level2">
<h2>Analysis results</h2>
<p>Enrichment analyses are summarized by the following three quantities.</p>
<ul>
<li><strong>BF:</strong> Bayes factor comparing the enrichment model against the baseline model;</li>
<li><strong>Outside <span class="math inline">\(\pi\)</span>:</strong> proportion of trait-associated SNPs that are “outside” the gene set;</li>
<li><strong>Inside <span class="math inline">\(\pi\)</span>:</strong> proportion of trait-associated SNPs that are “inside” the gene set.</li>
</ul>
<p>The first quantity reflects the significance of enrichment, whereas the last two capture the magnitude of enrichment. For each gene set, we report these three quantities in the last three columns of tables below, on log 10 scale.</p>
<div id="biological-pathways" class="section level3">
<h3>Biological pathways</h3>
<div id="htmlwidget-983860bb2d7d6ad3a872" style="width:100%;height:auto;" class="datatables html-widget"></div>
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induction of chemokines<br/>(235, reactome, PC)","IL 4 signaling pathway<br/>(1165, biocarta, BioCarta)","JAK/STAT signaling pathway<br/>(1431, panther, PANTHER)","JAK/STAT signaling pathway<br/>(1478, panther, PC)","Scavenging of heme from plasma<br/>(1355, reactome, BioSystems)","IL-10 Anti-inflammatory Signaling Pathway<br/>(1724, biocarta, BioCarta)","Scavenging of heme from plasma<br/>(1410, reactome, PC)","STING mediated induction of host immune responses<br/>(1647, reactome, PC)","STING mediated induction of host immune responses<br/>(1741, reactome, BioSystems)","IL22 Soluble Receptor Signaling Pathway <br/>(1657, biocarta, BioCarta)","JAK-STAT signaling<br/>(1859, kegg, BioSystems)","Regulation by TREX1<br/>(126, reactome, BioSystems)","V-type ATPase, eukaryotes<br/>(1980, kegg, BioSystems)","Signaling by FGFR1 fusion mutants<br/>(1802, reactome, BioSystems)","Signaling by FGFR1 fusion mutants<br/>(1836, reactome, PC)","Collecting duct acid secretion<br/>(2184, kegg, BioSystems)","Insulin receptor recycling<br/>(2060, reactome, PC)","Transferrin endocytosis and recycling<br/>(2211, reactome, PC)","UTP and CTP dephosphorylation I<br/>(79, humancyc, PC)","Thiamine metabolism<br/>(407, kegg, PC)","Osteoblast Signaling<br/>(1453, wiki, BioSystems)","pyrimidine deoxyribonucleotides de novo biosynthesis<br/>(1531, biocyc, BioSystems)","pyrimidine deoxyribonucleotides de novo biosynthesis<br/>(1501, humancyc, PC)","Interleukin-11 Signaling Pathway<br/>(2737, wiki, BioSystems)","Formation of the Editosome<br/>(26, reactome, PC)","Overview of telomerase protein component gene hTert Transcriptional Regulation <br/>(963, biocarta, BioCarta)","Overview of telomerase RNA component gene hTerc Transcriptional Regulation<br/>(739, biocarta, BioCarta)","pyrimidine deoxyribonucleotides biosynthesis from CTP<br/>(1530, biocyc, BioSystems)","NADH repair<br/>(220, humancyc, PC)","Glycolysis, core module involving three-carbon compounds<br/>(1198, kegg, BioSystems)","Glycolysis Pathway<br/>(1067, biocarta, BioCarta)","AKAP95 role in mitosis and chromosome dynamics<br/>(1257, biocarta, BioCarta)","Lysosphingolipid and LPA receptors<br/>(1029, reactome, PC)","ECM proteoglycans<br/>(3036, reactome, PC)","Androgen/estrogene/progesterone biosynthesis<br/>(859, panther, PANTHER)","Class II GLUTs<br/>(365, reactome, PC)","Facilitative Na+-independent glucose transporters<br/>(1225, reactome, PC)","Facilitative Na+-independent glucose transporters<br/>(1434, reactome, BioSystems)","Hypertrophy Model<br/>(1921, wiki, BioSystems)","Osteopontin Signaling<br/>(1294, wiki, BioSystems)","Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds<br/>(3496, reactome, PC)","Osteoclast Signaling<br/>(1687, wiki, BioSystems)","Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds<br/>(3518, reactome, BioSystems)","pyrimidine deoxyribonucleotides biosynthesis from CTP<br/>(1500, humancyc, PC)","SLC-mediated transmembrane transport<br/>(3847, reactome, PC)","SLC-mediated transmembrane transport<br/>(3852, reactome, BioSystems)","Abacavir transmembrane transport<br/>(514, reactome, PC)","Platelet degranulation<br/>(3307, reactome, PC)","Abacavir transport and metabolism<br/>(1104, reactome, PC)","Irinotecan Pathway<br/>(1451, wiki, BioSystems)","Response to elevated platelet cytosolic Ca2+<br/>(3355, reactome, PC)","Alpha9 beta1 integrin signaling events<br/>(1988, pid, PC)","Alpha4 beta1 integrin signaling events<br/>(2513, pid, PC)","Osteopontin-mediated events<br/>(2431, pid, PC)","Osteopontin-mediated events<br/>(2508, pid, BioSystems)","Integrins in angiogenesis<br/>(2878, pid, BioSystems)","TGF Beta Signaling Pathway<br/>(3031, wiki, BioSystems)","VxPx cargo-targeting to cilium<br/>(1917, reactome, BioSystems)","FGF signaling pathway<br/>(2903, pid, BioSystems)","ABC transporters<br/>(2792, kegg, BioSystems)","HIF-2-alpha transcription factor network<br/>(2466, pid, PC)","FGF signaling pathway<br/>(3037, pid, PC)","Degradation of the extracellular matrix<br/>(3442, reactome, PC)","Integrins in angiogenesis<br/>(3113, pid, PC)","Iron uptake and transport<br/>(2693, reactome, PC)","Regulation of toll-like receptor signaling pathway<br/>(3521, wiki, BioSystems)","Toll-like receptor signaling pathway<br/>(3557, kegg, BioSystems)","Toll-like receptor signaling pathway<br/>(3525, wiki, BioSystems)","Fluoropyrimidine Activity<br/>(2543, wiki, BioSystems)","Endochondral Ossification<br/>(3208, wiki, BioSystems)","Beta1 integrin cell surface interactions<br/>(3177, pid, PC)","Beta3 integrin cell surface interactions<br/>(2717, pid, PC)","Direct p53 effectors<br/>(3683, pid, BioSystems)","Direct p53 effectors<br/>(3703, pid, PC)","Cargo trafficking to the periciliary membrane<br/>(2947, reactome, BioSystems)","HIF-1-alpha transcription factor network<br/>(3190, pid, BioSystems)","HIF-1-alpha transcription factor network<br/>(3201, pid, PC)","Dopamine receptors<br/>(535, reactome, PC)","Bile secretion<br/>(3277, kegg, BioSystems)","Integrin cell surface interactions<br/>(3212, reactome, PC)","BDNF signaling pathway<br/>(3695, wiki, BioSystems)","Interactions of Tat with host cellular proteins<br/>(38, reactome, PC)","ECM-receptor interaction<br/>(3433, kegg, BioSystems)","Assembly of the primary cilium<br/>(3764, reactome, BioSystems)","Organic anion transport<br/>(560, reactome, PC)"],[3,3,2,2,6,32,3,2,3,3,4,7,8,30,3,10,13,14,12,17,13,16,17,16,19,2,21,18,19,25,23,26,2,4,13,14,14,40,2,8,6,14,3,10,9,11,9,54,7,4,11,13,20,11,95,16,98,14,251,254,5,74,10,13,79,22,33,31,32,46,53,20,47,42,32,54,87,60,39,98,102,98,33,65,64,40,133,139,49,64,65,5,70,66,136,2,85,173,5],[448,440,107,128,402,2569,322,244,357,177,284,591,732,2465,151,755,960,1040,912,1178,980,1222,1232,1305,1411,61,1698,1822,1867,1910,1877,2178,193,449,1348,1006,1080,3489,68,633,509,1044,317,565,761,804,899,6368,890,506,963,1126,1872,850,8901,1531,9319,1118,24511,25015,628,7107,1059,1210,7995,2694,3391,3304,3382,4731,5469,2419,4514,4488,2815,5134,9202,6412,3287,6897,6977,6993,3927,7640,7651,4417,11732,12072,4961,6189,6792,528,7652,6992,15052,126,10856,15460,203],[266.28000326499,259.203567402452,169.027524778921,168.936823283061,148.16926167787,147.050376708475,124.260604697085,118.304111490201,117.849805622383,106.504179904108,90.4453262913629,90.2196361479438,90.1293429452683,89.1101091939424,79.952845216418,78.7860650464579,78.4468090896821,78.3570477279642,78.2645420805294,78.2548170700128,78.2231358642033,78.2075182806876,78.2008848907324,78.0387338661254,77.9653170925628,61.0456055295643,36.3019912703306,36.2605941885139,36.2384140584108,36.2165840998572,36.1130419473146,36.0333198887983,33.6403853638814,32.5597639734383,30.5777033282904,22.9328807903003,22.8784671558234,20.4822137612889,17.186042022994,15.8364987198677,15.8018410595038,13.8512015128793,13.4127314525132,13.2977758545562,12.9340735746197,12.903882546152,12.7205693008184,10.1320613140682,7.99181202830945,4.46983536157177,3.88025186076616,3.7365044856572,3.29581501547673,2.94107356874082,2.1524787074074,2.12837135808539,2.10254672927043,1.88919299856142,1.74464376780345,1.72221389645729,1.5354863341169,1.42477957995859,1.27280520470042,1.2418317347754,1.22087465560582,1.19201942957057,1.03219959502223,1.02310770106651,1.01271528180793,0.901145499869511,0.883026267593747,0.874078233629166,0.869487073581359,0.842346218890626,0.83497989665281,0.819520537261118,0.795053597955482,0.76902582451406,0.754908300586606,0.710742290772339,0.708383743648952,0.705087402283046,0.677265795738498,0.674164470692398,0.670425230051171,0.655572126755367,0.608884690887733,0.593909118413841,0.586715624200434,0.520642996923815,0.473097752622221,0.456412739972863,0.445856859957165,0.417590262892949,0.410066272969638,0.282576584398098,0.272854684995326,0.116349031842244,0.0903086361099219],["-5.3409<br/>[-5.6089, -5.1455]","-5.3409<br/>[-5.6089, -5.1455]","-5.3409<br/>[-5.6089, -5.1454]","-5.3409<br/>[-5.6089, -5.1454]","-5.3408<br/>[-5.6088, -5.1453]","-5.3409<br/>[-5.6084, -5.1459]","-5.3408<br/>[-5.6088, -5.1453]","-5.3408<br/>[-5.6089, -5.1453]","-5.3408<br/>[-5.6088, -5.1453]","-5.3408<br/>[-5.6089, -5.1454]","-5.3408<br/>[-5.6088, -5.1453]","-5.3407<br/>[-5.6087, -5.1452]","-5.3406<br/>[-5.6087, -5.1452]","-5.3402<br/>[-5.6081, -5.1449]","-5.3409<br/>[-5.6089, -5.1453]","-5.3407<br/>[-5.6087, -5.1452]","-5.3406<br/>[-5.6086, -5.1451]","-5.3406<br/>[-5.6086, -5.1451]","-5.3408<br/>[-5.6087, -5.1455]","-5.3405<br/>[-5.6085, -5.1451]","-5.3408<br/>[-5.6087, -5.1454]","-5.3405<br/>[-5.6085, -5.1451]","-5.3405<br/>[-5.6085, -5.1451]","-5.3405<br/>[-5.6085, -5.1450]","-5.3404<br/>[-5.6084, -5.1450]","-5.3409<br/>[-5.6089, -5.1454]","-5.3404<br/>[-5.6083, -5.1450]","-5.3404<br/>[-5.6083, -5.1450]","-5.3403<br/>[-5.6083, -5.1450]","-5.3404<br/>[-5.6083, -5.1450]","-5.3404<br/>[-5.6083, -5.1450]","-5.3402<br/>[-5.6081, -5.1449]","-5.3409<br/>[-5.6089, -5.1454]","-5.3408<br/>[-5.6088, -5.1454]","-5.3432<br/>[-5.6102, -5.1483]","-5.3406<br/>[-5.6086, -5.1452]","-5.3406<br/>[-5.6086, -5.1452]","-5.3399<br/>[-5.6077, -5.1446]","-5.3409<br/>[-5.6089, -5.1454]","-5.3408<br/>[-5.6088, -5.1454]","-5.3407<br/>[-5.6087, -5.1452]","-5.3407<br/>[-5.6086, -5.1453]","-5.3408<br/>[-5.6088, -5.1454]","-5.3408<br/>[-5.6088, -5.1454]","-5.3407<br/>[-5.6087, -5.1453]","-5.3407<br/>[-5.6087, -5.1453]","-5.3406<br/>[-5.6086, -5.1451]","-5.3390<br/>[-5.6066, -5.1439]","-5.3406<br/>[-5.6086, -5.1451]","-5.4415<br/>[-5.8327, -5.2069]","-5.4414<br/>[-5.8326, -5.2068]","-5.4413<br/>[-5.8325, -5.2067]","-5.3406<br/>[-5.6122, -5.1453]","-5.3407<br/>[-5.6087, -5.1453]","-5.4422<br/>[-5.8321, -5.2087]","-5.3405<br/>[-5.6084, -5.1451]","-5.4421<br/>[-5.8319, -5.2086]","-5.3407<br/>[-5.6086, -5.1453]","-5.4440<br/>[-5.8315, -5.2125]","-5.4438<br/>[-5.8313, -5.2123]","-5.4414<br/>[-5.8185, -5.2068]","-5.3391<br/>[-5.6103, -5.1441]","-5.4412<br/>[-5.8184, -5.2067]","-5.4411<br/>[-5.8183, -5.2065]","-5.3387<br/>[-5.6100, -5.1438]","-5.3404<br/>[-5.6081, -5.1452]","-5.3400<br/>[-5.6078, -5.1448]","-5.3400<br/>[-5.6078, -5.1447]","-5.3399<br/>[-5.6077, -5.1447]","-5.3398<br/>[-5.6074, -5.1447]","-5.3400<br/>[-5.6073, -5.1453]","-5.4408<br/>[-5.8179, -5.2063]","-5.3395<br/>[-5.6073, -5.1443]","-5.4406<br/>[-5.8174, -5.2064]","-5.4409<br/>[-5.8179, -5.2065]","-5.3394<br/>[-5.6071, -5.1442]","-5.3401<br/>[-5.6064, -5.1462]","-5.3393<br/>[-5.6068, -5.1444]","-5.4407<br/>[-5.8177, -5.2062]","-5.3390<br/>[-5.6065, -5.1440]","-5.3390<br/>[-5.6065, -5.1440]","-5.3389<br/>[-5.6065, -5.1439]","-5.4405<br/>[-5.8174, -5.2061]","-5.3390<br/>[-5.6063, -5.1442]","-5.3389<br/>[-5.6063, -5.1440]","-5.3400<br/>[-5.6075, -5.1450]","-5.3383<br/>[-5.6052, -5.1438]","-5.3382<br/>[-5.6050, -5.1437]","-5.4403<br/>[-5.8171, -5.2060]","-5.4405<br/>[-5.8170, -5.2065]","-5.4403<br/>[-5.8168, -5.2063]","-5.3409<br/>[-5.6089, -5.1455]","-5.4407<br/>[-5.8171, -5.2069]","-5.3389<br/>[-5.6065, -5.1440]","-5.3364<br/>[-5.6035, -5.1419]","-5.3420<br/>[-5.6095, -5.1469]","-5.3381<br/>[-5.6052, -5.1435]","-5.4388<br/>[-5.8144, -5.2056]","-5.3428<br/>[-5.6100, -5.1480]"],["-2.1479<br/>[-2.1673, -2.1199]","-2.1369<br/>[-2.1663, -2.0989]","-1.4157<br/>[-1.4245, -1.4029]","-1.4904<br/>[-1.5028, -1.4757]","-2.1219<br/>[-2.1263, -2.1163]","-2.8826<br/>[-2.9268, -2.8446]","-2.0146<br/>[-2.2004, -1.9866]","-2.0756<br/>[-2.0856, -2.0635]","-2.2430<br/>[-2.2508, -2.2318]","-1.9196<br/>[-1.9454, -1.8854]","-2.1472<br/>[-2.1518, -2.1390]","-2.4633<br/>[-2.4704, -2.4527]","-2.5563<br/>[-2.5631, -2.5468]","-3.0758<br/>[-3.0897, -3.0555]","-1.8757<br/>[-1.8777, -1.8723]","-2.5727<br/>[-2.5764, -2.5666]","-2.6778<br/>[-2.6809, -2.6733]","-2.7127<br/>[-2.7156, -2.7076]","-2.6533<br/>[-2.6584, -2.6464]","-2.7674<br/>[-2.7699, -2.7638]","-2.6846<br/>[-2.6895, -2.6772]","-2.7830<br/>[-2.7857, -2.7786]","-2.7865<br/>[-2.7892, -2.7821]","-2.8119<br/>[-2.8143, -2.8081]","-2.8459<br/>[-2.8482, -2.8418]","-1.4763<br/>[-1.4836, -1.4641]","-2.8903<br/>[-2.9276, -2.8409]","-2.9196<br/>[-2.9571, -2.8671]","-2.9308<br/>[-2.9693, -2.8812]","-2.9379<br/>[-2.9779, -2.8846]","-2.9359<br/>[-2.9721, -2.8890]","-3.0034<br/>[-3.0360, -2.9604]","-1.7803<br/>[-1.8055, -1.7525]","-2.1519<br/>[-2.1688, -2.1273]","-2.3607<br/>[-2.3710, -2.3345]","-2.6719<br/>[-2.7006, -2.6342]","-2.6992<br/>[-2.7304, -2.6543]","-2.6830<br/>[-2.6914, -2.6629]","-1.1564<br/>[-1.1680, -1.1373]","-2.4314<br/>[-2.4970, -2.3484]","-2.3863<br/>[-2.4052, -2.3560]","-2.5297<br/>[-2.5516, -2.4923]","-2.0061<br/>[-2.0227, -1.9831]","-2.2274<br/>[-2.2695, -2.1812]","-2.3673<br/>[-2.4012, -2.3250]","-2.3926<br/>[-2.4243, -2.3535]","-2.4471<br/>[-2.4740, -2.4116]","-2.8020<br/>[-2.8109, -2.7789]","-2.6424<br/>[-2.6483, -2.6319]","-2.3340<br/>[-2.3990, -2.2599]","-2.6226<br/>[-2.6784, -2.5487]","-2.6937<br/>[-2.7473, -2.6259]","-2.8018<br/>[-2.9134, -2.5990]","-2.8612<br/>[-2.9292, -2.7482]","-3.5204<br/>[-3.6358, -3.3875]","-3.1097<br/>[-3.1847, -2.9700]","-3.5444<br/>[-3.6586, -3.4139]","-2.1455<br/>[-2.1622, -2.1194]","-3.9320<br/>[-4.0709, -3.8035]","-3.9427<br/>[-4.0795, -3.8144]","-2.6518<br/>[-2.7977, -2.4718]","-3.3908<br/>[-3.5400, -3.2078]","-2.9059<br/>[-3.0244, -2.7390]","-2.9659<br/>[-3.0823, -2.7834]","-3.4491<br/>[-3.8882, -3.3418]","-3.2508<br/>[-3.4295, -3.0346]","-3.3991<br/>[-3.5269, -3.2049]","-3.4039<br/>[-3.5184, -3.2281]","-3.4142<br/>[-3.5277, -3.2337]","-3.5335<br/>[-3.6739, -3.3469]","-3.5441<br/>[-3.7357, -3.3067]","-3.3025<br/>[-3.3832, -3.1705]","-3.5568<br/>[-3.6538, -3.4076]","-3.4062<br/>[-3.6508, -3.1030]","-3.3435<br/>[-3.4483, -3.1903]","-3.6058<br/>[-3.7094, -3.4409]","-3.6433<br/>[-3.9546, -3.3626]","-3.6604<br/>[-3.8052, -3.4685]","-3.4181<br/>[-3.5162, -3.2651]","-3.7183<br/>[-3.8364, -3.5404]","-3.7203<br/>[-3.8413, -3.5384]","-3.7238<br/>[-3.8420, -3.5427]","-3.4968<br/>[-3.5932, -3.3436]","-3.7422<br/>[-3.8803, -3.5524]","-3.7421<br/>[-3.8816, -3.5471]","-3.5254<br/>[-3.6438, -3.3578]","-3.8317<br/>[-4.0633, -3.5615]","-3.8454<br/>[-4.0735, -3.5657]","-3.5951<br/>[-3.6940, -3.4364]","-3.6573<br/>[-3.7892, -3.4793]","-3.7036<br/>[-3.8299, -3.5310]","-2.6982<br/>[-3.2273, -2.5159]","-3.7365<br/>[-3.8804, -3.5479]","-3.7562<br/>[-3.8429, -3.6170]","-4.0238<br/>[-4.1732, -3.8096]","-2.0610<br/>[-4.4168, -1.7673]","-3.9210<br/>[-4.0331, -3.7514]","-4.0634<br/>[-4.1852, -3.8929]","-2.4073<br/>[-4.4785, -2.0234]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Pathway name<br/>(ID, database, repository)<\/th>\n <th># of genes<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2,3]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 3, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="tissue-highly-expressed-genes" class="section level3">
<h3>Tissue highly expressed genes</h3>
<div id="htmlwidget-0aaad034f4771159c3b9" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-0aaad034f4771159c3b9">{"x":{"filter":"none","data":[["Spleen","Muscle - Skeletal","Small Intestine - Terminal Ileum","Cells - EBV-transformed lymphocytes","Lung","Testis","Heart - Left Ventricle","Colon - Transverse","Stomach","Pancreas","Adrenal Gland","Nerve - Tibial","Heart - Atrial Appendage","Whole Blood","Brain - Cerebellar Hemisphere","Breast - Mammary Tissue","Brain - Frontal Cortex (BA9)","Ovary","Skin - Not Sun Exposed (Suprapubic)","Esophagus - Mucosa","Prostate","Brain - Cerebellum","Skin - Sun Exposed (Lower leg)","Esophagus - Gastroesophageal Junction","Adipose - Subcutaneous","Uterus","Brain - Cortex","Brain - Hippocampus","Colon - Sigmoid","Cells - Transformed fibroblasts","Brain - Anterior cingulate cortex (BA24)","Vagina","Esophagus - Muscularis","Adipose - Visceral (Omentum)","Brain - Hypothalamus","Pituitary","Artery - Tibial","Artery - Coronary","Thyroid","Liver","Artery - Aorta","Brain - Nucleus accumbens (basal ganglia)","Brain - Caudate (basal ganglia)","Brain - Putamen (basal ganglia)"],[4072,5736,4744,5007,5062,5914,5703,5301,5319,5163,5701,5745,5926,5904,5718,5620,6262,5937,5848,5651,5654,5768,5768,5858,5684,5742,5930,5818,5963,6150,5977,5850,6047,5904,5946,5946,6095,6223,6210,6368,6399,6158,6530,6606],[-0.31492936394221,-0.324917033185395,-0.3302594966413,-0.334026680955904,-0.335849319419722,-0.336505735052317,-0.342080460126464,-0.342289644214514,-0.343211476931061,-0.343759469623389,-0.344566431789305,-0.349907693796057,-0.350324281374297,-0.352248871560991,-0.352531637092906,-0.352549813810859,-0.352857541009687,-0.352984557173437,-0.353036693104669,-0.353289964134757,-0.35365143486176,-0.353767625652216,-0.353959233479051,-0.354117402036615,-0.354355878550872,-0.354435063960567,-0.354475735798211,-0.354667484922385,-0.356086876157886,-0.356697907819625,-0.357230412020864,-0.357325277170726,-0.35815387818665,-0.358498926224002,-0.35862131621232,-0.358959890799003,-0.359757830775366,-0.363738017208288,-0.363926043227275,-0.365531180083242,-0.365904650539745,-0.366154558255704,-0.372705781082519,-0.373525561789034],["-5.3396<br/>[-5.6075, -5.1443]","-5.3400<br/>[-5.6073, -5.1453]","-5.3395<br/>[-5.6072, -5.1443]","-5.3395<br/>[-5.6072, -5.1443]","-5.3395<br/>[-5.6071, -5.1443]","-5.3397<br/>[-5.6071, -5.1448]","-5.3395<br/>[-5.6070, -5.1445]","-5.3394<br/>[-5.6071, -5.1442]","-5.3394<br/>[-5.6070, -5.1442]","-5.3393<br/>[-5.6071, -5.1441]","-5.3394<br/>[-5.6070, -5.1444]","-5.3393<br/>[-5.6069, -5.1442]","-5.3394<br/>[-5.6069, -5.1443]","-5.3393<br/>[-5.6069, -5.1442]","-5.3392<br/>[-5.6069, -5.1441]","-5.3392<br/>[-5.6069, -5.1440]","-5.3394<br/>[-5.6068, -5.1444]","-5.3392<br/>[-5.6068, -5.1441]","-5.3392<br/>[-5.6068, -5.1440]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6069, -5.1441]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6069, -5.1441]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6069, -5.1441]","-5.3392<br/>[-5.6069, -5.1440]","-5.3392<br/>[-5.6068, -5.1441]","-5.3390<br/>[-5.6067, -5.1439]","-5.3392<br/>[-5.6068, -5.1440]","-5.3392<br/>[-5.6068, -5.1440]","-5.3392<br/>[-5.6068, -5.1441]","-5.3391<br/>[-5.6068, -5.1440]","-5.3391<br/>[-5.6068, -5.1440]","-5.3391<br/>[-5.6068, -5.1440]","-5.3392<br/>[-5.6068, -5.1441]","-5.3391<br/>[-5.6067, -5.1440]","-5.3391<br/>[-5.6067, -5.1440]","-5.3391<br/>[-5.6067, -5.1440]","-5.3391<br/>[-5.6067, -5.1440]","-5.3390<br/>[-5.6067, -5.1438]","-5.3389<br/>[-5.6066, -5.1438]","-5.3389<br/>[-5.6065, -5.1438]"],["-4.8870<br/>[-6.5727, -4.2831]","-4.5952<br/>[-6.1495, -4.0312]","-4.8705<br/>[-6.4862, -4.2744]","-4.8355<br/>[-6.4687, -4.2417]","-4.8460<br/>[-6.4770, -4.2504]","-4.6633<br/>[-6.2233, -4.0862]","-4.7551<br/>[-6.3354, -4.1641]","-4.8722<br/>[-6.4908, -4.2777]","-4.8824<br/>[-6.4993, -4.2910]","-4.9590<br/>[-6.5702, -4.3689]","-4.7897<br/>[-6.3862, -4.1995]","-4.8610<br/>[-6.4443, -4.2771]","-4.8127<br/>[-6.4070, -4.2239]","-4.8478<br/>[-6.4490, -4.2578]","-4.9071<br/>[-6.4762, -4.3158]","-4.9454<br/>[-6.5081, -4.3548]","-4.7751<br/>[-6.3495, -4.1920]","-4.8459<br/>[-6.4678, -4.2457]","-4.8706<br/>[-6.5177, -4.2682]","-4.9463<br/>[-6.5366, -4.3562]","-4.9540<br/>[-6.5429, -4.3670]","-4.9136<br/>[-6.5008, -4.3272]","-4.9161<br/>[-6.5248, -4.3232]","-4.8918<br/>[-6.4787, -4.3051]","-4.9561<br/>[-6.5449, -4.3684]","-4.9353<br/>[-6.5224, -4.3476]","-4.8727<br/>[-6.4622, -4.2854]","-4.9108<br/>[-6.5036, -4.3222]","-4.8920<br/>[-6.4734, -4.3068]","-4.8361<br/>[-6.5432, -4.2216]","-4.9035<br/>[-6.4904, -4.3152]","-4.9506<br/>[-6.5327, -4.3644]","-4.9009<br/>[-6.4793, -4.3156]","-4.9532<br/>[-6.5033, -4.3662]","-4.9394<br/>[-6.5214, -4.3524]","-4.9469<br/>[-6.5255, -4.3609]","-4.9132<br/>[-6.4853, -4.3282]","-4.9427<br/>[-6.4772, -4.3581]","-4.9478<br/>[-6.5172, -4.3624]","-4.9319<br/>[-6.4838, -4.3522]","-4.9250<br/>[-6.4862, -4.3426]","-5.0099<br/>[-6.5735, -4.4250]","-5.0059<br/>[-6.5533, -4.4245]","-4.9954<br/>[-6.5118, -4.4137]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Tissue name<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="tissue-selectively-expressed-genes" class="section level3">
<h3>Tissue selectively expressed genes</h3>
<div id="htmlwidget-9dd0ac780160f191cf9f" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-9dd0ac780160f191cf9f">{"x":{"filter":"none","data":[["Pituitary","Kidney_Cortex","Brain_Cortex","Brain_Amygdala","Brain_Spinal_cord_(cervical_c-1)","Brain_Anterior_cingulate_cortex_(BA24)","Brain_Frontal_Cortex_(BA9)","Whole_Blood","Spleen","Liver","Skin_Sun_Exposed_(Lower_leg)","Skin_Not_Sun_Exposed_(Suprapubic)","Nerve_Tibial","Colon_Transverse","Vagina","Testis","Esophagus_Mucosa","Lung","Cells_EBV-transformed_lymphocytes","Stomach","Muscle_Skeletal","Pancreas","Minor_Salivary_Gland","Ovary","Small_Intestine_Terminal_Ileum","Prostate","Breast_Mammary_Tissue","Brain_Cerebellum","Adipose_Visceral_(Omentum)","Brain_Hippocampus","Uterus","Adipose_Subcutaneous","Brain_Nucleus_accumbens_(basal_ganglia)","Colon_Sigmoid","Cells_Transformed_fibroblasts","Brain_Caudate_(basal_ganglia)","Brain_Putamen_(basal_ganglia)","Heart_Left_Ventricle","Heart_Atrial_Appendage","Brain_Hypothalamus","Thyroid","Adrenal_Gland","Brain_Substantia_nigra","Artery_Coronary","Brain_Cerebellar_Hemisphere","Artery_Tibial","Esophagus_Gastroesophageal_Junction","Esophagus_Muscularis","Artery_Aorta"],[9481,8969,11954,11191,12666,12957,13617,7210,7222,8164,6798,6872,12396,7496,6774,7684,6855,8350,7815,9260,8648,7674,8352,11511,8688,9103,9816,10879,9885,10921,12498,10142,11319,10936,10706,11653,11717,10999,11080,12180,11931,12167,12650,12332,13466,12507,14061,14219,14209],[2.19517353201496,0.898659408947123,0.656636237075528,0.648490733580237,0.644221061092592,0.624617114745736,0.57037898187972,-0.312760625745882,-0.329232427377061,-0.344065375977416,-0.351695118820382,-0.353095526775079,-0.363607573005374,-0.376737995417471,-0.379783835113974,-0.380691696652692,-0.381037632353286,-0.382845473905291,-0.382993201139519,-0.38582717324647,-0.390318007603958,-0.393684293087461,-0.401566261633379,-0.408005835466423,-0.413534616290982,-0.414380384002403,-0.416703836306451,-0.421149330519943,-0.427670273863826,-0.427734744445788,-0.432464227323873,-0.433287250348939,-0.435007276592355,-0.436904904225484,-0.439899850256363,-0.440592209576747,-0.44286632990514,-0.444246146780202,-0.446872067096528,-0.448235912908757,-0.453708815216605,-0.455078974436105,-0.457692887267011,-0.458241350717069,-0.458713673319674,-0.459444454873499,-0.475329090666621,-0.477489793238006,-0.485341328638611],["-5.3393<br/>[-5.6060, -5.1451]","-5.3432<br/>[-5.6088, -5.1495]","-5.3384<br/>[-5.6051, -5.1442]","-5.3381<br/>[-5.6051, -5.1437]","-5.3371<br/>[-5.6043, -5.1424]","-5.3382<br/>[-5.6048, -5.1441]","-5.3379<br/>[-5.6045, -5.1438]","-5.3406<br/>[-5.6073, -5.1463]","-5.3403<br/>[-5.6071, -5.1458]","-5.3416<br/>[-5.6079, -5.1473]","-5.3393<br/>[-5.6067, -5.1445]","-5.3393<br/>[-5.6067, -5.1445]","-5.3420<br/>[-5.6066, -5.1496]","-5.3392<br/>[-5.6065, -5.1444]","-5.3388<br/>[-5.6064, -5.1436]","-5.3391<br/>[-5.6064, -5.1443]","-5.3388<br/>[-5.6064, -5.1436]","-5.3389<br/>[-5.6061, -5.1441]","-5.3387<br/>[-5.6062, -5.1437]","-5.3397<br/>[-5.6064, -5.1454]","-5.3391<br/>[-5.6062, -5.1445]","-5.3386<br/>[-5.6062, -5.1436]","-5.3385<br/>[-5.6060, -5.1436]","-5.3386<br/>[-5.6053, -5.1444]","-5.3382<br/>[-5.6057, -5.1431]","-5.3383<br/>[-5.6057, -5.1434]","-5.3384<br/>[-5.6056, -5.1438]","-5.3386<br/>[-5.6054, -5.1442]","-5.3380<br/>[-5.6054, -5.1431]","-5.3383<br/>[-5.6052, -5.1438]","-5.3387<br/>[-5.6051, -5.1447]","-5.3378<br/>[-5.6052, -5.1429]","-5.3381<br/>[-5.6051, -5.1435]","-5.3379<br/>[-5.6051, -5.1432]","-5.3377<br/>[-5.6051, -5.1429]","-5.3379<br/>[-5.6049, -5.1434]","-5.3378<br/>[-5.6049, -5.1433]","-5.3376<br/>[-5.6049, -5.1428]","-5.3375<br/>[-5.6049, -5.1427]","-5.3378<br/>[-5.6048, -5.1433]","-5.3372<br/>[-5.6046, -5.1424]","-5.3374<br/>[-5.6046, -5.1428]","-5.3375<br/>[-5.6045, -5.1430]","-5.3371<br/>[-5.6044, -5.1423]","-5.3377<br/>[-5.6044, -5.1435]","-5.3371<br/>[-5.6044, -5.1423]","-5.3370<br/>[-5.6040, -5.1425]","-5.3370<br/>[-5.6039, -5.1424]","-5.3365<br/>[-5.6037, -5.1418]"],["-2.7741<br/>[-2.7765, -2.7517]","-3.6844<br/>[-3.9381, -3.4008]","-3.7870<br/>[-4.0750, -3.5342]","-3.7962<br/>[-4.0443, -3.5711]","-3.9873<br/>[-4.0999, -3.8202]","-3.8171<br/>[-4.1070, -3.5576]","-3.8620<br/>[-4.1311, -3.6147]","-4.3779<br/>[-5.9317, -3.7949]","-4.4807<br/>[-6.0179, -3.9047]","-4.5848<br/>[-5.7325, -4.1275]","-4.6753<br/>[-6.3209, -4.0806]","-4.6782<br/>[-6.3217, -4.0832]","-4.5298<br/>[-5.8669, -4.0518]","-4.8508<br/>[-6.2861, -4.2919]","-5.0614<br/>[-6.6059, -4.4813]","-4.8676<br/>[-6.3262, -4.3168]","-5.0587<br/>[-6.5958, -4.4812]","-4.7792<br/>[-6.3507, -4.1955]","-4.8337<br/>[-6.4512, -4.2294]","-4.7428<br/>[-6.0504, -4.2104]","-4.8325<br/>[-6.2686, -4.2850]","-5.0441<br/>[-6.5444, -4.4714]","-5.0081<br/>[-6.4510, -4.4419]","-4.6803<br/>[-6.2315, -4.0840]","-5.1290<br/>[-6.5942, -4.5621]","-5.0386<br/>[-6.5023, -4.4745]","-4.9619<br/>[-6.3799, -4.4103]","-4.8718<br/>[-6.2581, -4.3183]","-5.0889<br/>[-6.5317, -4.5288]","-4.9313<br/>[-6.3292, -4.3736]","-4.8444<br/>[-6.2158, -4.3057]","-5.1283<br/>[-6.5716, -4.5650]","-4.9655<br/>[-6.3667, -4.4113]","-5.0478<br/>[-6.4205, -4.5027]","-5.1266<br/>[-6.5021, -4.5732]","-4.9851<br/>[-6.3860, -4.4288]","-5.0044<br/>[-6.3714, -4.4487]","-5.1395<br/>[-6.5454, -4.5863]","-5.1665<br/>[-6.5702, -4.6142]","-5.0144<br/>[-6.3621, -4.4633]","-5.1175<br/>[-6.5834, -4.5445]","-5.1002<br/>[-6.4826, -4.5511]","-5.0725<br/>[-6.4417, -4.5272]","-5.1199<br/>[-6.5519, -4.5417]","-4.9938<br/>[-6.3485, -4.4538]","-5.1109<br/>[-6.5645, -4.5363]","-5.1233<br/>[-6.4365, -4.5917]","-5.1320<br/>[-6.4410, -4.5980]","-5.2435<br/>[-6.5808, -4.7037]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Tissue name<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="cluster-distinctively-expressed-genes" class="section level3">
<h3>Cluster distinctively expressed genes</h3>
<div id="htmlwidget-798b325e8770e69abc2e" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-798b325e8770e69abc2e">{"x":{"filter":"none","data":[["9","14","5","4","17","7","1","19","2","13","12","15","18","10","6","20","11","8","16","3"],[9469,9348,11358,12270,8470,8199,7462,5891,8913,7566,7200,7701,7224,8330,8785,8051,10242,10113,10172,9998],[0.865080730610407,0.556840275119535,0.523787240227745,0.454719139731209,-0.35856928563399,-0.362860179306846,-0.364954170351802,-0.370676167244778,-0.38123206799156,-0.386076291602575,-0.387302370781404,-0.392315873260535,-0.396576742670965,-0.398689785196556,-0.405232170332373,-0.409257288396737,-0.42237284699619,-0.423019509015796,-0.430051113516732,-0.436129523033367],["-5.3390<br/>[-5.6059, -5.1446]","-5.3382<br/>[-5.6056, -5.1434]","-5.4387<br/>[-5.8150, -5.2048]","-5.3378<br/>[-5.6086, -5.1434]","-5.3403<br/>[-5.6067, -5.1463]","-5.3396<br/>[-5.6065, -5.1451]","-5.3392<br/>[-5.6065, -5.1444]","-5.3391<br/>[-5.6068, -5.1439]","-5.3405<br/>[-5.6069, -5.1463]","-5.3391<br/>[-5.6064, -5.1443]","-5.3389<br/>[-5.6064, -5.1440]","-5.3390<br/>[-5.6063, -5.1442]","-5.3387<br/>[-5.6063, -5.1436]","-5.3388<br/>[-5.6061, -5.1440]","-5.3388<br/>[-5.6060, -5.1441]","-5.3385<br/>[-5.6060, -5.1435]","-5.3386<br/>[-5.6056, -5.1441]","-5.3382<br/>[-5.6054, -5.1435]","-5.3384<br/>[-5.6055, -5.1438]","-5.3381<br/>[-5.6054, -5.1433]"],["-3.7527<br/>[-3.9739, -3.4967]","-3.8348<br/>[-3.9680, -3.6526]","-3.9008<br/>[-4.0531, -3.6654]","-3.9129<br/>[-4.0856, -3.7203]","-4.5297<br/>[-6.0519, -3.9633]","-4.5590<br/>[-6.1800, -3.9697]","-4.5988<br/>[-6.3239, -3.9748]","-5.0100<br/>[-6.5491, -4.4224]","-4.6964<br/>[-5.9537, -4.1934]","-4.8305<br/>[-6.3434, -4.2599]","-4.9048<br/>[-6.4434, -4.3239]","-4.8899<br/>[-6.3608, -4.3304]","-5.0565<br/>[-6.5828, -4.4780]","-4.8417<br/>[-6.3969, -4.2547]","-4.8597<br/>[-6.3534, -4.2863]","-5.0525<br/>[-6.5474, -4.4786]","-4.8715<br/>[-6.2747, -4.3098]","-4.8759<br/>[-6.4136, -4.2787]","-4.9583<br/>[-6.3802, -4.4018]","-5.0675<br/>[-6.4894, -4.5100]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Cluster ID<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
<p>The relationship between tissues and clusters is shown in Figure 1 of <a href="http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006599">Dey et al. (2017)</a>; see below.</p>
<p><img src="http://journals.plos.org/plosgenetics/article/figure/image?size=large&id=10.1371/journal.pgen.1006599.g001" /></p>
</div>
</div>
<div id="session-information" class="section level2">
<h2>Session information</h2>
<div class="sourceCode" id="cb1"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb1-1" data-line-number="1">devtools<span class="op">::</span><span class="kw">session_info</span>()</a></code></pre></div>
<pre><code>Session info -------------------------------------------------------------</code></pre>
<pre><code> setting value
version R version 3.5.1 (2018-07-02)
system x86_64, darwin15.6.0
ui X11
language (EN)
collate en_US.UTF-8
tz America/Los_Angeles
date 2018-10-05 </code></pre>
<pre><code>Packages -----------------------------------------------------------------</code></pre>
<pre><code> package * version date source
assertthat 0.2.0 2017-04-11 CRAN (R 3.5.0)
backports 1.1.2 2017-12-13 CRAN (R 3.5.0)
base * 3.5.1 2018-07-05 local
bindr 0.1.1 2018-03-13 CRAN (R 3.5.0)
bindrcpp 0.2.2 2018-03-29 CRAN (R 3.5.0)
compiler 3.5.1 2018-07-05 local
crayon 1.3.4 2017-09-16 CRAN (R 3.5.0)
crosstalk 1.0.0 2016-12-21 CRAN (R 3.5.0)
datasets * 3.5.1 2018-07-05 local
devtools 1.13.6 2018-06-27 CRAN (R 3.5.0)
digest 0.6.17 2018-09-12 CRAN (R 3.5.0)
dplyr * 0.7.6 2018-06-29 CRAN (R 3.5.1)
DT * 0.4 2018-01-30 CRAN (R 3.5.0)
evaluate 0.11 2018-07-17 CRAN (R 3.5.0)
git2r 0.23.0 2018-07-17 CRAN (R 3.5.0)
glue 1.3.0 2018-07-17 CRAN (R 3.5.0)
graphics * 3.5.1 2018-07-05 local
grDevices * 3.5.1 2018-07-05 local
htmltools 0.3.6 2017-04-28 CRAN (R 3.5.0)
htmlwidgets 1.3 2018-09-30 CRAN (R 3.5.0)
httpuv 1.4.5 2018-07-19 CRAN (R 3.5.0)
jsonlite 1.5 2017-06-01 CRAN (R 3.5.0)
knitr 1.20 2018-02-20 CRAN (R 3.5.0)
later 0.7.5 2018-09-18 CRAN (R 3.5.0)
magrittr 1.5 2014-11-22 CRAN (R 3.5.0)
memoise 1.1.0 2017-04-21 CRAN (R 3.5.0)
methods * 3.5.1 2018-07-05 local
mime 0.5 2016-07-07 CRAN (R 3.5.0)
pillar 1.3.0 2018-07-14 CRAN (R 3.5.0)
pkgconfig 2.0.2 2018-08-16 CRAN (R 3.5.0)
plyr * 1.8.4 2016-06-08 CRAN (R 3.5.0)
promises 1.0.1 2018-04-13 CRAN (R 3.5.0)
purrr 0.2.5 2018-05-29 CRAN (R 3.5.0)
R.matlab * 3.6.2 2018-09-27 CRAN (R 3.5.0)
R.methodsS3 1.7.1 2016-02-16 CRAN (R 3.5.0)
R.oo 1.22.0 2018-04-22 CRAN (R 3.5.0)
R.utils 2.7.0 2018-08-27 CRAN (R 3.5.0)
R6 2.3.0 2018-10-04 CRAN (R 3.5.0)
Rcpp 0.12.19 2018-10-01 CRAN (R 3.5.0)
rlang 0.2.2 2018-08-16 CRAN (R 3.5.0)
rmarkdown 1.10 2018-06-11 CRAN (R 3.5.0)
rprojroot 1.3-2 2018-01-03 CRAN (R 3.5.0)
shiny 1.1.0 2018-05-17 CRAN (R 3.5.0)
stats * 3.5.1 2018-07-05 local
stringi 1.2.4 2018-07-20 CRAN (R 3.5.0)
stringr 1.3.1 2018-05-10 CRAN (R 3.5.0)
tibble 1.4.2 2018-01-22 CRAN (R 3.5.0)
tidyselect 0.2.4 2018-02-26 CRAN (R 3.5.0)
tools 3.5.1 2018-07-05 local
utils * 3.5.1 2018-07-05 local
whisker 0.3-2 2013-04-28 CRAN (R 3.5.0)
withr 2.1.2 2018-03-15 CRAN (R 3.5.0)
workflowr 1.1.1 2018-07-06 CRAN (R 3.5.0)
xtable 1.8-3 2018-08-29 CRAN (R 3.5.0)
yaml 2.2.0 2018-07-25 CRAN (R 3.5.0)</code></pre>
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