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<h1 class="title toc-ignore">Enrichment results of body mass index</h1>
<h4 class="author"><em>Xiang Zhu</em></h4>
<h4 class="date"><em>2017-04-12</em></h4>
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<p><strong>Last updated:</strong> 2018-10-05</p>
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<div id="input-data" class="section level2">
<h2>Input data</h2>
<p>Results below were generated from the GWAS summary statistics published in the paper <a href="https://www.ncbi.nlm.nih.gov/pubmed/25673413">“Genetic Studies of Body Mass Index Yield New Insights for Obesity Biology” (<em>Nature</em>, 2015)</a>. The summary data file is available at <a href="https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files" class="uri">https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files</a>.</p>
</div>
<div id="analysis-results" class="section level2">
<h2>Analysis results</h2>
<p>Enrichment analyses are summarized by the following three quantities.</p>
<ul>
<li><strong>BF:</strong> Bayes factor comparing the enrichment model against the baseline model;</li>
<li><strong>Outside <span class="math inline">\(\pi\)</span>:</strong> proportion of trait-associated SNPs that are “outside” the gene set;</li>
<li><strong>Inside <span class="math inline">\(\pi\)</span>:</strong> proportion of trait-associated SNPs that are “inside” the gene set.</li>
</ul>
<p>The first quantity reflects the significance of enrichment, whereas the last two capture the magnitude of enrichment. For each gene set, we report these three quantities in the last three columns of tables below, on log 10 scale.</p>
<div id="biological-pathways" class="section level3">
<h3>Biological pathways</h3>
<div id="htmlwidget-983860bb2d7d6ad3a872" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-983860bb2d7d6ad3a872">{"x":{"filter":"none","data":[["Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone<br/>(619, kegg, BioSystems)","ubiquinol-10 biosynthesis<br/>(479, biocyc, BioSystems)","Pyridoxal phosphate salvage pathway<br/>(53, panther, PC)","Vitamin B6 metabolism<br/>(117, panther, PANTHER)","Ubiquinone and other terpenoid-quinone biosynthesis<br/>(1300, kegg, BioSystems)","Ubiquinol biosynthesis<br/>(824, reactome, PC)","Ubiquinone and other...<br/>(946, kegg, PC)","Calcitonin-like ligand receptors<br/>(1112, reactome, PC)","NADH dehydrogenase (ubiquinone) 1 beta subcomplex<br/>(1448, kegg, BioSystems)","Vitamin B6 metabolism<br/>(253, panther, PC)","Vitamins B6 activation to pyridoxal phosphate<br/>(254, reactome, PC)","pyridoxal 5'-phosphate salvage<br/>(646, biocyc, BioSystems)","pyridoxal 5'-phosphate salvage<br/>(594, humancyc, PC)","Assembly of the ORC complex at the origin of replication<br/>(655, reactome, PC)","Orexin and neuropeptides FF and QRFP bind to their respective receptors<br/>(924, reactome, PC)","Regulation of signaling by NODAL<br/>(1143, reactome, PC)","FSH signaling pathway<br/>(2267, wiki, BioSystems)","Metabotropic glutamate receptor group II pathway<br/>(2308, panther, PANTHER)","Sodium-coupled phosphate cotransporters<br/>(568, reactome, PC)","Methylmalonyl pathway<br/>(378, panther, PC)","Cohesin Loading onto Chromatin<br/>(794, reactome, PC)","Acetate utilization<br/>(178, panther, PC)","Cohesin Loading onto Chromatin<br/>(975, reactome, BioSystems)","oxidative ethanol degradation III<br/>(718, humancyc, PC)","ethanol degradation II<br/>(712, humancyc, PC)","Lysine biosynthesis<br/>(171, kegg, BioSystems)","Formation of the active cofactor, UDP-glucuronate<br/>(205, reactome, PC)","serotonin degradation<br/>(756, biocyc, BioSystems)","serotonin degradation<br/>(837, humancyc, PC)","Ethanol oxidation<br/>(1120, reactome, PC)","Fatty Acid Omega Oxidation<br/>(1608, wiki, BioSystems)","Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD<br/>(132, reactome, BioSystems)","Release of apoptotic factors from the mitochondria<br/>(58, reactome, PC)","Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2<br/>(229, reactome, PC)","N-glycan precursor trimming<br/>(776, kegg, BioSystems)","Degradation of aromatic compounds<br/>(139, kegg, BioSystems)","Proton-coupled neutral amino acid transporters<br/>(52, reactome, PC)","Ascorbate degradation<br/>(120, panther, PANTHER)","cardiolipin biosynthesis<br/>(164, biocyc, BioSystems)","Proton/oligonucleotide cotransporters<br/>(392, reactome, PC)","Organic cation transport<br/>(926, reactome, PC)","urea cycle<br/>(440, humancyc, PC)","Urea cycle<br/>(636, kegg, BioSystems)","Polyamine biosynthesis, arginine => ornithine => putrescine<br/>(325, kegg, BioSystems)","Urea cycle<br/>(947, reactome, PC)","Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline<br/>(728, biocarta, BioCarta)","Dopamine Neurotransmitter Release Cycle<br/>(1976, reactome, BioSystems)","S1P5 pathway<br/>(933, pid, PC)","Regulation by TREX1<br/>(126, reactome, BioSystems)","Urea cycle and metabolism of amino groups<br/>(1809, wiki, BioSystems)","Arginine biosynthesis<br/>(1816, kegg, BioSystems)","Neurotransmitter Release Cycle<br/>(2897, reactome, BioSystems)","Cul4-DDB1-CSA complex<br/>(486, kegg, BioSystems)","4-hydroxyproline degradation<br/>(344, humancyc, PC)","ketolysis<br/>(420, humancyc, PC)","Acyl chain remodeling of DAG and TAG<br/>(518, reactome, PC)","Exosome, archaea<br/>(484, kegg, BioSystems)","Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells<br/>(564, reactome, PC)","ketogenesis<br/>(476, biocyc, BioSystems)","ketogenesis<br/>(589, humancyc, PC)","Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells<br/>(816, reactome, PC)","Tachykinin receptors bind tachykinins<br/>(575, reactome, PC)","SMAC binds to IAPs<br/>(400, reactome, PC)","tetrapyrrole biosynthesis<br/>(337, biocyc, BioSystems)","Reversal of Alkylation Damage By DNA Dioxygenases<br/>(60, reactome, PC)","Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate<br/>(885, kegg, BioSystems)","Estrogen biosynthesis<br/>(24, reactome, PC)","coenzyme A biosynthesis<br/>(618, biocyc, BioSystems)","Coenzyme A biosynthesis, pantothenate => CoA<br/>(880, kegg, BioSystems)","coenzyme A biosynthesis<br/>(710, humancyc, PC)","Coenzyme A biosynthesis<br/>(906, reactome, PC)","ChREBP activates metabolic gene expression<br/>(905, reactome, PC)","Vitamin B5 (pantothenate) metabolism<br/>(1249, reactome, PC)","tetrapyrrole biosynthesis<br/>(437, humancyc, PC)","G2 Phase<br/>(543, reactome, PC)","Defective MUT causes methylmalonic aciduria mut type<br/>(130, reactome, BioSystems)","Erythrocytes take up carbon dioxide and release oxygen<br/>(1018, reactome, PC)","Sodium-coupled sulphate, di- and tri-carboxylate transporters<br/>(569, reactome, PC)","cardiolipin biosynthesis<br/>(257, humancyc, PC)","MAPK (ERK5) signaling<br/>(468, kegg, BioSystems)","Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes<br/>(226, reactome, PC)","N-glycan trimming and elongation in the cis-Golgi<br/>(554, reactome, PC)","creatine-phosphate biosynthesis<br/>(478, biocyc, BioSystems)","creatine-phosphate biosynthesis<br/>(583, humancyc, PC)","Ahr Signal Transduction Pathway<br/>(441, biocarta, BioCarta)","Creatine pathway<br/>(884, kegg, BioSystems)","IRAK4 deficiency (TLR5)<br/>(462, reactome, BioSystems)","Abacavir metabolism<br/>(513, reactome, PC)","superoxide radicals degradation<br/>(436, humancyc, PC)","PKA-mediated phosphorylation of key metabolic factors<br/>(384, reactome, PC)","Succinate dehydrogenase (ubiquinone)<br/>(494, kegg, BioSystems)","SCF-SKP2 complex<br/>(489, kegg, BioSystems)","creatine biosynthesis<br/>(90, humancyc, PC)","Regulators of Bone Mineralization<br/>(451, biocarta, BioCarta)","Aurora C signaling<br/>(340, pid, BioSystems)","Breakdown of the nuclear lamina<br/>(189, reactome, PC)","Regulation of gene expression in early pancreatic precursor cells<br/>(930, reactome, PC)","pyrimidine ribonucleosides degradation<br/>(277, humancyc, PC)","Hemoglobin's Chaperone<br/>(1164, biocarta, BioCarta)"],[5,4,2,2,11,7,8,10,13,3,3,5,5,6,8,10,27,28,5,4,7,3,8,6,6,2,3,6,7,10,15,2,2,3,6,2,2,2,2,4,8,4,5,3,8,6,21,8,2,18,18,47,4,4,4,5,4,5,4,5,7,5,4,3,2,7,2,5,7,6,8,8,11,4,5,2,9,5,3,4,3,5,4,5,4,7,4,5,4,4,4,4,2,4,3,3,8,3,10],[398,434,166,180,727,643,667,827,798,259,346,391,385,346,668,716,2383,2393,284,417,562,309,653,493,502,194,250,264,300,533,653,112,172,382,497,175,223,127,124,512,573,392,497,294,659,436,2737,644,61,1359,1448,5303,182,312,283,435,252,377,302,329,643,536,385,208,210,597,252,308,450,395,511,464,673,263,273,139,545,561,265,207,263,511,228,244,237,368,220,343,435,248,318,267,124,486,264,194,737,350,708],[187.750835793027,177.964505569933,159.701173124628,158.973809008811,152.140858497749,151.581626052815,151.536383317742,130.788807301094,125.651397463056,112.207887882393,111.812077625652,111.762655425305,111.749591751178,111.387793123187,108.168318040778,108.015426878291,104.060295225073,104.035730172961,95.3299722455212,90.5870402427377,90.5384615004836,90.5182711388503,90.4239015990616,90.1089614230814,90.0488804569378,77.3377305811387,76.8670981360187,74.2694328345999,74.104631194306,71.9910543523824,71.7783983857445,70.8196638986872,69.2879619874962,69.1518670445442,68.9354824366948,66.4466837446025,65.0797120536189,63.669707028921,62.4179845773981,60.818409215073,59.8392547634321,51.765909437553,51.5185770891123,51.4944781580125,51.1958347467438,51.1280541282928,51.0474023278692,50.9117654075103,50.7558742011855,50.5525547558102,50.35196455239,50.2787115056211,50.2179154035255,49.918421274478,49.4060320712286,49.2166347307847,46.8800784214107,45.2617895264046,45.1244213748159,45.0491041674647,44.6693787221748,44.6655287922655,41.8670695590613,41.7560586270494,41.6378241872791,40.9129557979956,40.6795279685339,40.4814931486336,40.347490253385,40.267431552695,40.2280787028025,40.1667312225707,39.9969782619492,38.7458135172391,35.3651225268931,33.0320651473763,32.9872031677186,32.4912349361064,32.1691536433147,31.8623024899128,31.625517761595,29.1059380490888,28.1054404667109,28.0741517497835,27.9360977545491,27.6633454396667,27.5124872240346,27.2957122616423,22.5181432415571,22.2481510820161,21.4199911402809,20.6315391962044,20.5514240971279,19.9485505572431,17.0870831670746,16.9961259904163,-0.0641184411035839,-0.419272056048792,-0.513263673957452],["-4.1511<br/>[-4.2314, -4.0871]","-4.1511<br/>[-4.2314, -4.0872]","-4.1513<br/>[-4.2315, -4.0873]","-4.1512<br/>[-4.2315, -4.0872]","-4.1523<br/>[-4.2323, -4.0886]","-4.1511<br/>[-4.2313, -4.0871]","-4.1510<br/>[-4.2313, -4.0871]","-4.1523<br/>[-4.2325, -4.0883]","-4.1510<br/>[-4.2313, -4.0871]","-4.1512<br/>[-4.2315, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1511<br/>[-4.2314, -4.0871]","-4.1516<br/>[-4.2318, -4.0876]","-4.1510<br/>[-4.2313, -4.0870]","-4.1511<br/>[-4.2312, -4.0872]","-4.1507<br/>[-4.2309, -4.0867]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1518<br/>[-4.2320, -4.0878]","-4.1513<br/>[-4.2315, -4.0873]","-4.1518<br/>[-4.2319, -4.0878]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1573<br/>[-4.2388, -4.0924]","-4.1573<br/>[-4.2388, -4.0924]","-4.1512<br/>[-4.2314, -4.0872]","-4.1510<br/>[-4.2313, 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-4.0873]","-4.1511<br/>[-4.2313, -4.0871]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1513<br/>[-4.2315, -4.0873]","-4.1511<br/>[-4.2313, -4.0871]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1513<br/>[-4.2315, -4.0873]","-4.1511<br/>[-4.2314, -4.0871]","-4.1512<br/>[-4.2314, -4.0873]","-4.1511<br/>[-4.2314, -4.0871]","-4.1512<br/>[-4.2314, -4.0873]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1511<br/>[-4.2313, -4.0871]","-4.1511<br/>[-4.2313, -4.0871]","-4.1568<br/>[-4.2380, -4.0922]","-4.1583<br/>[-4.2399, -4.0935]","-4.1512<br/>[-4.2314, -4.0872]","-4.1511<br/>[-4.2313, -4.0871]","-4.1515<br/>[-4.2318, -4.0876]","-4.1516<br/>[-4.2318, -4.0876]","-4.1512<br/>[-4.2314, -4.0872]","-4.1515<br/>[-4.2317, -4.0876]","-4.1512<br/>[-4.2315, -4.0872]","-4.1516<br/>[-4.2318, -4.0876]","-4.1511<br/>[-4.2313, -4.0871]","-4.1512<br/>[-4.2314, -4.0872]","-4.1511<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1519<br/>[-4.2322, -4.0879]","-4.1512<br/>[-4.2314, -4.0872]","-4.1512<br/>[-4.2315, -4.0872]","-4.1512<br/>[-4.2314, -4.0872]","-4.1511<br/>[-4.2314, -4.0871]","-4.1510<br/>[-4.2313, -4.0870]"],["-1.9774<br/>[-1.9938, -1.9612]","-2.1314<br/>[-2.1549, -2.1051]","-1.5098<br/>[-1.5485, -1.4815]","-1.6348<br/>[-1.6487, -1.6203]","-2.3704<br/>[-2.4477, -2.3079]","-2.4773<br/>[-2.5048, -2.4424]","-2.4991<br/>[-2.5210, -2.4688]","-2.2785<br/>[-2.3069, -2.2504]","-2.5234<br/>[-2.5927, -2.2447]","-1.9738<br/>[-2.0596, -1.9052]","-2.1309<br/>[-2.2120, -2.0851]","-2.1712<br/>[-2.2639, -2.1061]","-2.1649<br/>[-2.2598, -2.0995]","-1.9154<br/>[-1.9355, -1.8265]","-2.4343<br/>[-2.5057, -2.3643]","-2.5382<br/>[-2.5526, -2.5174]","-2.9649<br/>[-3.0475, -2.8786]","-2.9733<br/>[-3.0514, -2.8950]","-2.1370<br/>[-2.1516, -2.1168]","-2.2965<br/>[-2.3178, -2.2703]","-2.3715<br/>[-2.4274, -2.3075]","-2.1225<br/>[-2.1817, -2.0685]","-2.4323<br/>[-2.4961, -2.3832]","-2.3387<br/>[-2.3884, -2.2921]","-2.3491<br/>[-2.3940, -2.3023]","-1.9705<br/>[-1.9863, -1.9491]","-2.0802<br/>[-2.0961, -2.0579]","-1.9318<br/>[-1.9431, -1.9180]","-1.9852<br/>[-1.9982, -1.9689]","-2.3668<br/>[-2.4180, -2.3142]","-2.4865<br/>[-2.5122, -2.4532]","-1.2583<br/>[-1.2675, -1.2480]","-1.5589<br/>[-1.5963, -1.5245]","-2.2588<br/>[-2.2798, -2.2295]","-2.3736<br/>[-2.3948, -2.3462]","-1.6299<br/>[-1.6394, -1.6192]","-2.0305<br/>[-2.0465, -2.0081]","-1.3885<br/>[-1.4011, -1.3744]","-1.3760<br/>[-1.3909, -1.3602]","-2.3930<br/>[-2.4073, -2.3725]","-2.2347<br/>[-2.2750, -2.1904]","-2.1349<br/>[-2.2071, -2.0740]","-2.2379<br/>[-2.3281, -2.1720]","-2.1374<br/>[-2.1667, -2.1024]","-2.3716<br/>[-2.4663, -2.3018]","-2.3194<br/>[-2.3376, -2.2940]","-2.9183<br/>[-2.9568, -2.8777]","-2.4134<br/>[-2.4946, -2.3306]","-0.8670<br/>[-0.8766, -0.8561]","-2.6748<br/>[-2.7954, -2.5875]","-2.7436<br/>[-2.8398, -2.6663]","-3.2009<br/>[-3.2412, -3.1556]","-1.7597<br/>[-1.7804, -1.7362]","-2.1661<br/>[-2.1925, -2.1323]","-1.9520<br/>[-1.9714, -1.9275]","-2.3183<br/>[-2.3362, -2.2928]","-2.0865<br/>[-2.1001, -2.0683]","-2.1541<br/>[-2.2496, -2.0775]","-2.1618<br/>[-2.1785, -2.1393]","-2.1992<br/>[-2.2156, -2.1766]","-2.4484<br/>[-2.4985, -2.4025]","-2.4088<br/>[-2.4275, -2.3846]","-2.1813<br/>[-2.2689, -2.1036]","-1.7900<br/>[-1.8280, -1.7502]","-1.8113<br/>[-1.8422, -1.7787]","-2.4336<br/>[-2.4732, -2.3855]","-2.0556<br/>[-2.0965, -2.0093]","-2.1461<br/>[-2.1839, -2.1041]","-2.2443<br/>[-2.3339, -2.1661]","-2.2566<br/>[-2.2922, -2.2150]","-2.3058<br/>[-2.3954, -2.2312]","-2.3203<br/>[-2.3613, -2.2738]","-2.4204<br/>[-2.5118, -2.3361]","-2.0758<br/>[-2.1180, -2.0305]","-2.1151<br/>[-2.1342, -2.0882]","-1.8118<br/>[-1.8412, -1.7741]","-2.3968<br/>[-2.4332, -2.3475]","-2.4131<br/>[-2.4463, -2.3691]","-1.9223<br/>[-1.9438, -1.8951]","-1.6924<br/>[-1.7201, -1.6624]","-2.0871<br/>[-2.1170, -2.0479]","-2.3751<br/>[-2.4064, -2.3347]","-1.9428<br/>[-2.0218, -1.8731]","-1.9685<br/>[-2.0458, -1.8962]","-2.0361<br/>[-2.0726, -1.9905]","-2.1551<br/>[-2.2339, -2.0819]","-1.9984<br/>[-2.0396, -1.9533]","-2.0598<br/>[-2.1519, -1.9641]","-2.3198<br/>[-2.3371, -2.2963]","-2.0592<br/>[-2.0918, -2.0163]","-2.1669<br/>[-2.2009, -2.1274]","-2.1013<br/>[-2.1244, -2.0692]","-1.7525<br/>[-1.7898, -1.7085]","-2.3370<br/>[-2.3836, -2.2803]","-2.0879<br/>[-2.1197, -2.0466]","-1.8810<br/>[-1.9810, -1.7852]","-2.8699<br/>[-3.4605, -2.6455]","-3.8776<br/>[-5.1225, -3.3097]","-4.0104<br/>[-5.0045, -3.4919]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Pathway name<br/>(ID, database, repository)<\/th>\n <th># of genes<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2,3]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 3, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="tissue-highly-expressed-genes" class="section level3">
<h3>Tissue highly expressed genes</h3>
<div id="htmlwidget-0aaad034f4771159c3b9" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-0aaad034f4771159c3b9">{"x":{"filter":"none","data":[["Esophagus - Gastroesophageal Junction","Colon - Sigmoid","Pancreas","Esophagus - Muscularis","Artery - Tibial","Artery - Aorta","Pituitary","Thyroid","Muscle - Skeletal","Cells - EBV-transformed lymphocytes","Stomach","Nerve - Tibial","Prostate","Breast - Mammary Tissue","Cells - Transformed fibroblasts","Uterus","Adipose - Visceral (Omentum)","Vagina","Skin - Sun Exposed (Lower leg)","Skin - Not Sun Exposed (Suprapubic)","Adipose - Subcutaneous","Ovary","Brain - Cerebellum","Heart - Atrial Appendage","Heart - Left Ventricle","Small Intestine - Terminal Ileum","Spleen","Brain - Cortex","Brain - Anterior cingulate cortex (BA24)","Brain - Frontal Cortex (BA9)","Brain - Cerebellar Hemisphere","Colon - Transverse","Brain - Hypothalamus","Lung","Brain - Hippocampus","Adrenal Gland","Brain - Nucleus accumbens (basal ganglia)","Brain - Caudate (basal ganglia)","Whole Blood","Brain - Putamen (basal ganglia)","Testis","Esophagus - Mucosa","Artery - Coronary","Liver"],[5376,5471,4681,5552,5632,5920,5443,5778,5168,4554,4934,5307,5165,5126,5670,5245,5470,5388,5304,5369,5278,5464,5321,5224,4986,4343,3726,5500,5563,5838,5311,4897,5499,4696,5405,5063,5718,6019,5495,6134,5379,5295,5744,5735],[0.991878767772252,0.953332561836416,0.744731874891814,0.453802801722695,0.392703821668817,0.372382572303494,0.253011183777068,0.166169559385876,0.152778893497891,-0.176339006417236,-0.234927658447187,-0.250175524342907,-0.251442428049652,-0.282096591168898,-0.291487566406993,-0.304379950728906,-0.317559065047959,-0.317926174084335,-0.318532181540448,-0.320479155713355,-0.321668084040485,-0.326258103372181,-0.497293468674473,-0.516123232769565,-0.560652823665209,-0.561002994104126,-0.563473779018953,-0.568377395005087,-0.574917200650774,-0.590937017246994,-0.607229964746078,-0.608632987326494,-0.625286240980198,-0.626045296773604,-0.628778648450787,-0.634420856920353,-0.646005315223408,-0.650686046401989,-0.651205045831107,-0.657552042479927,-0.658524680626296,-0.660371901035593,-0.67366854082656,-0.677059586452407],["-4.1539<br/>[-4.2341, -4.0899]","-4.1538<br/>[-4.2340, -4.0898]","-4.1557<br/>[-4.2355, -4.0919]","-4.1539<br/>[-4.2340, -4.0898]","-4.1535<br/>[-4.2337, -4.0894]","-4.1534<br/>[-4.2336, -4.0893]","-4.1495<br/>[-4.2297, -4.0857]","-4.1555<br/>[-4.2368, -4.0907]","-4.1527<br/>[-4.2327, -4.0879]","-4.1500<br/>[-4.2301, -4.0862]","-4.1498<br/>[-4.2300, -4.0860]","-4.1498<br/>[-4.2299, -4.0860]","-4.1498<br/>[-4.2299, -4.0859]","-4.1496<br/>[-4.2297, -4.0857]","-4.1496<br/>[-4.2297, -4.0858]","-4.1495<br/>[-4.2296, -4.0856]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2295, -4.0855]","-4.1511<br/>[-4.2309, -4.0875]","-4.1509<br/>[-4.2311, -4.0870]","-4.1504<br/>[-4.2306, -4.0864]","-4.1500<br/>[-4.2302, -4.0861]","-4.1501<br/>[-4.2302, -4.0862]","-4.1506<br/>[-4.2307, -4.0867]","-4.1505<br/>[-4.2306, -4.0866]","-4.1504<br/>[-4.2305, -4.0865]","-4.1499<br/>[-4.2300, -4.0861]","-4.1499<br/>[-4.2300, -4.0860]","-4.1498<br/>[-4.2299, -4.0859]","-4.1497<br/>[-4.2298, -4.0858]","-4.1498<br/>[-4.2299, -4.0859]","-4.1496<br/>[-4.2297, -4.0857]","-4.1496<br/>[-4.2297, -4.0858]","-4.1496<br/>[-4.2297, -4.0857]","-4.1494<br/>[-4.2295, -4.0854]","-4.1495<br/>[-4.2296, -4.0857]","-4.1494<br/>[-4.2296, -4.0855]","-4.1494<br/>[-4.2296, -4.0855]","-4.1493<br/>[-4.2295, -4.0854]","-4.1493<br/>[-4.2294, -4.0854]"],["-3.3273<br/>[-3.4304, -3.2272]","-3.3474<br/>[-3.4435, -3.2530]","-3.0751<br/>[-3.3352, -2.9031]","-3.6027<br/>[-3.7278, -3.4645]","-3.6705<br/>[-3.7586, -3.5615]","-3.6914<br/>[-3.7785, -3.5884]","-3.3335<br/>[-3.4258, -3.2320]","-3.3823<br/>[-3.4604, -3.2972]","-3.3388<br/>[-3.5112, -3.2081]","-3.5005<br/>[-3.6456, -3.3467]","-3.5593<br/>[-3.6840, -3.4240]","-3.5719<br/>[-3.7098, -3.4308]","-3.5736<br/>[-3.7015, -3.4338]","-3.6053<br/>[-3.7141, -3.4766]","-3.6103<br/>[-3.7387, -3.4685]","-3.6286<br/>[-3.7290, -3.5056]","-3.6417<br/>[-3.7431, -3.5216]","-3.6425<br/>[-3.7407, -3.5224]","-3.6456<br/>[-3.7369, -3.5335]","-3.6463<br/>[-3.7420, -3.5307]","-3.6505<br/>[-3.7367, -3.5450]","-3.6512<br/>[-3.7474, -3.5331]","-3.8114<br/>[-4.3035, -3.5087]","-3.8686<br/>[-4.2277, -3.5663]","-4.0231<br/>[-4.3608, -3.7474]","-4.0874<br/>[-4.6137, -3.7125]","-4.2864<br/>[-4.8478, -3.8966]","-3.9956<br/>[-4.3313, -3.7260]","-4.0110<br/>[-4.3407, -3.7448]","-4.0358<br/>[-4.3478, -3.7691]","-4.1435<br/>[-4.6095, -3.8176]","-4.2327<br/>[-4.7535, -3.8955]","-4.2028<br/>[-4.6328, -3.8873]","-4.4304<br/>[-4.9622, -4.0623]","-4.2404<br/>[-4.6720, -3.9210]","-4.3582<br/>[-4.9029, -3.9952]","-4.2709<br/>[-4.7252, -3.9487]","-4.2371<br/>[-4.6713, -3.9163]","-4.3608<br/>[-4.8249, -4.0247]","-4.2537<br/>[-4.6831, -3.9349]","-4.4594<br/>[-4.9709, -4.1016]","-4.5137<br/>[-5.0658, -4.1458]","-4.4647<br/>[-4.9595, -4.1124]","-4.5032<br/>[-5.0207, -4.1547]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Tissue name<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="tissue-selectively-expressed-genes" class="section level3">
<h3>Tissue selectively expressed genes</h3>
<div id="htmlwidget-9dd0ac780160f191cf9f" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-9dd0ac780160f191cf9f">{"x":{"filter":"none","data":[["Esophagus_Gastroesophageal_Junction","Kidney_Cortex","Esophagus_Muscularis","Pancreas","Artery_Tibial","Artery_Coronary","Artery_Aorta","Breast_Mammary_Tissue","Brain_Hypothalamus","Muscle_Skeletal","Minor_Salivary_Gland","Spleen","Pituitary","Prostate","Colon_Transverse","Small_Intestine_Terminal_Ileum","Adipose_Subcutaneous","Stomach","Brain_Amygdala","Brain_Putamen_(basal_ganglia)","Brain_Caudate_(basal_ganglia)","Brain_Hippocampus","Brain_Nucleus_accumbens_(basal_ganglia)","Brain_Cortex","Cells_Transformed_fibroblasts","Brain_Anterior_cingulate_cortex_(BA24)","Testis","Whole_Blood","Brain_Substantia_nigra","Skin_Sun_Exposed_(Lower_leg)","Vagina","Brain_Cerebellum","Skin_Not_Sun_Exposed_(Suprapubic)","Esophagus_Mucosa","Cells_EBV-transformed_lymphocytes","Brain_Frontal_Cortex_(BA9)","Lung","Liver","Heart_Left_Ventricle","Heart_Atrial_Appendage","Adipose_Visceral_(Omentum)","Colon_Sigmoid","Adrenal_Gland","Nerve_Tibial","Ovary","Brain_Cerebellar_Hemisphere","Brain_Spinal_cord_(cervical_c-1)","Uterus","Thyroid"],[12916,8237,13069,7067,11877,11769,13590,9173,11550,8074,8048,6774,9042,8519,7134,8237,9245,8699,10616,10733,10632,10380,10750,11280,10206,12256,7052,6781,12126,6558,6530,10336,6624,6606,7413,12953,8041,7209,10045,10093,9112,10455,11247,11787,10976,12932,12140,11710,11468],[0.45068980800964,0.447475450558517,0.435931784793664,0.185826788114089,0.142705216101974,0.0965807608211189,0.0262014890609377,-0.0623650039621086,-0.099880049359462,-0.233995896924031,-0.242046732118184,-0.249251149547161,-0.29897872211308,-0.409516282065026,-0.45398955805594,-0.45470677344185,-0.507990806631478,-0.592703408625014,-0.618468052490256,-0.642544327594139,-0.642789848940017,-0.64299244064571,-0.644492043569083,-0.677223585459095,-0.692645887869625,-0.701992353697626,-0.707328919736775,-0.714385679164797,-0.716873029826845,-0.716943652630818,-0.718145240040894,-0.71866738417727,-0.718957334002561,-0.721626671469209,-0.726190461190513,-0.742341333923357,-0.743388994610871,-0.745630040900297,-0.780451896536621,-0.7840730732976,-0.786982210002925,-0.791826456220375,-0.794882147663601,-0.798075459842648,-0.80959053107774,-0.834871844524207,-0.845771969855509,-0.858740160194413,-0.8726453678869],["-4.1588<br/>[-4.2401, -4.0941]","-4.1646<br/>[-4.2462, -4.0996]","-4.1587<br/>[-4.2400, -4.0940]","-4.1588<br/>[-4.2386, -4.0947]","-4.1525<br/>[-4.2326, -4.0886]","-4.1516<br/>[-4.2316, -4.0877]","-4.1508<br/>[-4.2308, -4.0869]","-4.1589<br/>[-4.2386, -4.0950]","-4.1504<br/>[-4.2285, -4.0873]","-4.1503<br/>[-4.2300, -4.0867]","-4.1570<br/>[-4.2366, -4.0929]","-4.1501<br/>[-4.2299, -4.0865]","-4.1505<br/>[-4.2301, -4.0869]","-4.1528<br/>[-4.2310, -4.0897]","-4.1529<br/>[-4.2330, -4.0885]","-4.1529<br/>[-4.2329, -4.0885]","-4.1543<br/>[-4.2351, -4.0899]","-4.1513<br/>[-4.2296, -4.0881]","-4.1505<br/>[-4.2286, -4.0874]","-4.1508<br/>[-4.2289, -4.0878]","-4.1508<br/>[-4.2289, -4.0877]","-4.1507<br/>[-4.2288, -4.0876]","-4.1508<br/>[-4.2289, -4.0877]","-4.1504<br/>[-4.2285, -4.0874]","-4.1485<br/>[-4.2285, -4.0847]","-4.1502<br/>[-4.2283, -4.0872]","-4.1492<br/>[-4.2293, -4.0854]","-4.1488<br/>[-4.2289, -4.0849]","-4.1501<br/>[-4.2282, -4.0871]","-4.1489<br/>[-4.2291, -4.0851]","-4.1489<br/>[-4.2291, -4.0850]","-4.1491<br/>[-4.2289, -4.0855]","-4.1489<br/>[-4.2291, -4.0850]","-4.1489<br/>[-4.2290, -4.0850]","-4.1487<br/>[-4.2288, -4.0848]","-4.1498<br/>[-4.2278, -4.0867]","-4.1485<br/>[-4.2287, -4.0847]","-4.1486<br/>[-4.2288, -4.0848]","-4.1485<br/>[-4.2285, -4.0847]","-4.1484<br/>[-4.2284, -4.0846]","-4.1482<br/>[-4.2282, -4.0843]","-4.1485<br/>[-4.2285, -4.0847]","-4.1486<br/>[-4.2284, -4.0850]","-4.1482<br/>[-4.2280, -4.0846]","-4.1484<br/>[-4.2283, -4.0846]","-4.1480<br/>[-4.2278, -4.0845]","-4.1477<br/>[-4.2276, -4.0841]","-4.1474<br/>[-4.2273, -4.0836]","-4.1470<br/>[-4.2271, -4.0832]"],["-3.6620<br/>[-3.7465, -3.5660]","-3.3217<br/>[-3.4807, -3.1927]","-3.6713<br/>[-3.7526, -3.5788]","-3.3240<br/>[-3.6286, -3.1421]","-3.8825<br/>[-3.9891, -3.7647]","-3.9409<br/>[-4.0442, -3.8216]","-4.0117<br/>[-4.1102, -3.9038]","-3.4945<br/>[-3.6910, -3.3554]","-3.5499<br/>[-3.7040, -3.4279]","-3.5747<br/>[-3.7509, -3.4248]","-3.5994<br/>[-3.7183, -3.4906]","-3.5823<br/>[-3.7285, -3.4472]","-3.6184<br/>[-3.8063, -3.4568]","-3.6583<br/>[-4.0051, -3.4180]","-3.7589<br/>[-3.9827, -3.5511]","-3.7396<br/>[-3.9998, -3.5165]","-3.8091<br/>[-3.9336, -3.6702]","-3.8998<br/>[-4.1492, -3.7024]","-3.8975<br/>[-4.1736, -3.6773]","-3.9364<br/>[-4.2097, -3.7246]","-3.9397<br/>[-4.2107, -3.7298]","-3.9459<br/>[-4.2157, -3.7364]","-3.9395<br/>[-4.1999, -3.7256]","-3.9821<br/>[-4.2342, -3.7697]","-4.0436<br/>[-4.3306, -3.8128]","-4.0006<br/>[-4.2638, -3.7895]","-4.3742<br/>[-4.7730, -4.0713]","-4.4944<br/>[-4.9868, -4.1741]","-4.0340<br/>[-4.2866, -3.8324]","-4.6024<br/>[-5.1032, -4.2648]","-4.6299<br/>[-5.1374, -4.2874]","-4.0774<br/>[-4.4735, -3.7744]","-4.5977<br/>[-5.1118, -4.2616]","-4.6384<br/>[-5.1454, -4.2936]","-4.4200<br/>[-4.8430, -4.0998]","-4.0594<br/>[-4.3081, -3.8576]","-4.4079<br/>[-4.7950, -4.0854]","-4.6760<br/>[-5.1537, -4.3351]","-4.3258<br/>[-4.6708, -4.0276]","-4.3386<br/>[-4.6800, -4.0422]","-4.5070<br/>[-4.9151, -4.1983]","-4.3402<br/>[-4.6547, -4.0806]","-4.2720<br/>[-4.6294, -3.9920]","-4.2455<br/>[-4.5904, -3.9792]","-4.3695<br/>[-4.6885, -4.1073]","-4.2982<br/>[-4.6616, -4.0229]","-4.4230<br/>[-4.7855, -4.1447]","-4.5696<br/>[-4.9549, -4.2727]","-4.7724<br/>[-5.1601, -4.4739]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Tissue name<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
</div>
<div id="cluster-distinctively-expressed-genes" class="section level3">
<h3>Cluster distinctively expressed genes</h3>
<div id="htmlwidget-798b325e8770e69abc2e" style="width:100%;height:auto;" class="datatables html-widget"></div>
<script type="application/json" data-for="htmlwidget-798b325e8770e69abc2e">{"x":{"filter":"none","data":[["4","18","1","15","7","13","9","2","10","16","8","19","20","11","12","17","14","6","3","5"],[11559,6708,6849,7361,7716,6988,8746,8288,7533,9514,9646,5235,7226,9742,6823,7906,8589,8216,8995,10630],[1.25713845575337,0.672869917365988,0.63342854219634,0.0925358171590848,-0.106423334588273,-0.242423195807774,-0.370656176355862,-0.432308940560017,-0.505855043544345,-0.523269318906841,-0.541104695913396,-0.594266051844812,-0.620435179284934,-0.631983536752557,-0.648585936175872,-0.674911832283006,-0.681532928413467,-0.69645471739728,-0.73816842164132,-0.75367838817037],["-4.1571<br/>[-4.2372, -4.0932]","-4.1619<br/>[-4.2427, -4.0976]","-4.1635<br/>[-4.2454, -4.0984]","-4.1538<br/>[-4.2357, -4.0892]","-4.1528<br/>[-4.2327, -4.0881]","-4.1498<br/>[-4.2298, -4.0860]","-4.1553<br/>[-4.2365, -4.0907]","-4.1517<br/>[-4.2300, -4.0885]","-4.1511<br/>[-4.2309, -4.0875]","-4.1503<br/>[-4.2343, -4.0842]","-4.1522<br/>[-4.2325, -4.0882]","-4.1495<br/>[-4.2296, -4.0856]","-4.1496<br/>[-4.2296, -4.0858]","-4.1506<br/>[-4.2303, -4.0870]","-4.1492<br/>[-4.2292, -4.0854]","-4.1486<br/>[-4.2288, -4.0848]","-4.1490<br/>[-4.2291, -4.0852]","-4.1489<br/>[-4.2289, -4.0851]","-4.1483<br/>[-4.2283, -4.0845]","-4.1485<br/>[-4.2284, -4.0847]"],["-3.3745<br/>[-3.5219, -3.2691]","-3.1727<br/>[-3.4543, -3.0121]","-3.2297<br/>[-3.4297, -3.0873]","-3.6767<br/>[-3.8241, -3.5197]","-3.4678<br/>[-3.6328, -3.2983]","-3.6117<br/>[-3.7528, -3.4599]","-3.7225<br/>[-3.8573, -3.5826]","-3.7453<br/>[-4.0593, -3.5073]","-3.8555<br/>[-4.2050, -3.5953]","-3.8883<br/>[-4.0001, -3.7750]","-3.9020<br/>[-4.0531, -3.7580]","-4.3653<br/>[-4.8662, -3.9940]","-4.1551<br/>[-4.5312, -3.8645]","-4.0379<br/>[-4.3167, -3.8198]","-4.3417<br/>[-4.8113, -4.0050]","-4.3079<br/>[-4.7230, -3.9943]","-4.2550<br/>[-4.5855, -3.9430]","-4.3836<br/>[-4.7869, -4.0811]","-4.5264<br/>[-4.9344, -4.2200]","-4.3698<br/>[-4.6712, -4.1132]"]],"container":"<table class=\"white-space: nowrap\">\n <thead>\n <tr>\n <th>Cluster ID<\/th>\n <th># of SNPs<\/th>\n <th>Log10 BF<\/th>\n <th>Log10 outside π<br/>(mean, 95% CI)<\/th>\n <th>Log10 inside π<br/>(mean, 95% CI)<\/th>\n <\/tr>\n <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[1,2]}],"order":[],"autoWidth":false,"orderClasses":false,"rowCallback":"function(row, data) {\nDTWidget.formatRound(this, row, data, 2, 3, 3, ',', '.');\n}"}},"evals":["options.rowCallback"],"jsHooks":[]}</script>
<p>The relationship between tissues and clusters is shown in Figure 1 of <a href="http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006599">Dey et al. (2017)</a>; see below.</p>
<p><img src="http://journals.plos.org/plosgenetics/article/figure/image?size=large&id=10.1371/journal.pgen.1006599.g001" /></p>
</div>
</div>
<div id="session-information" class="section level2">
<h2>Session information</h2>
<div class="sourceCode" id="cb1"><pre class="sourceCode r"><code class="sourceCode r"><a class="sourceLine" id="cb1-1" data-line-number="1">devtools<span class="op">::</span><span class="kw">session_info</span>()</a></code></pre></div>
<pre><code>Session info -------------------------------------------------------------</code></pre>
<pre><code> setting value
version R version 3.5.1 (2018-07-02)
system x86_64, darwin15.6.0
ui X11
language (EN)
collate en_US.UTF-8
tz America/Los_Angeles
date 2018-10-05 </code></pre>
<pre><code>Packages -----------------------------------------------------------------</code></pre>
<pre><code> package * version date source
assertthat 0.2.0 2017-04-11 CRAN (R 3.5.0)
backports 1.1.2 2017-12-13 CRAN (R 3.5.0)
base * 3.5.1 2018-07-05 local
bindr 0.1.1 2018-03-13 CRAN (R 3.5.0)
bindrcpp 0.2.2 2018-03-29 CRAN (R 3.5.0)
compiler 3.5.1 2018-07-05 local
crayon 1.3.4 2017-09-16 CRAN (R 3.5.0)
crosstalk 1.0.0 2016-12-21 CRAN (R 3.5.0)
datasets * 3.5.1 2018-07-05 local
devtools 1.13.6 2018-06-27 CRAN (R 3.5.0)
digest 0.6.17 2018-09-12 CRAN (R 3.5.0)
dplyr * 0.7.6 2018-06-29 CRAN (R 3.5.1)
DT * 0.4 2018-01-30 CRAN (R 3.5.0)
evaluate 0.11 2018-07-17 CRAN (R 3.5.0)
git2r 0.23.0 2018-07-17 CRAN (R 3.5.0)
glue 1.3.0 2018-07-17 CRAN (R 3.5.0)
graphics * 3.5.1 2018-07-05 local
grDevices * 3.5.1 2018-07-05 local
htmltools 0.3.6 2017-04-28 CRAN (R 3.5.0)
htmlwidgets 1.3 2018-09-30 CRAN (R 3.5.0)
httpuv 1.4.5 2018-07-19 CRAN (R 3.5.0)
jsonlite 1.5 2017-06-01 CRAN (R 3.5.0)
knitr 1.20 2018-02-20 CRAN (R 3.5.0)
later 0.7.5 2018-09-18 CRAN (R 3.5.0)
magrittr 1.5 2014-11-22 CRAN (R 3.5.0)
memoise 1.1.0 2017-04-21 CRAN (R 3.5.0)
methods * 3.5.1 2018-07-05 local
mime 0.5 2016-07-07 CRAN (R 3.5.0)
pillar 1.3.0 2018-07-14 CRAN (R 3.5.0)
pkgconfig 2.0.2 2018-08-16 CRAN (R 3.5.0)
plyr * 1.8.4 2016-06-08 CRAN (R 3.5.0)
promises 1.0.1 2018-04-13 CRAN (R 3.5.0)
purrr 0.2.5 2018-05-29 CRAN (R 3.5.0)
R.matlab * 3.6.2 2018-09-27 CRAN (R 3.5.0)
R.methodsS3 1.7.1 2016-02-16 CRAN (R 3.5.0)
R.oo 1.22.0 2018-04-22 CRAN (R 3.5.0)
R.utils 2.7.0 2018-08-27 CRAN (R 3.5.0)
R6 2.3.0 2018-10-04 CRAN (R 3.5.0)
Rcpp 0.12.19 2018-10-01 CRAN (R 3.5.0)
rlang 0.2.2 2018-08-16 CRAN (R 3.5.0)
rmarkdown 1.10 2018-06-11 CRAN (R 3.5.0)
rprojroot 1.3-2 2018-01-03 CRAN (R 3.5.0)
shiny 1.1.0 2018-05-17 CRAN (R 3.5.0)
stats * 3.5.1 2018-07-05 local
stringi 1.2.4 2018-07-20 CRAN (R 3.5.0)
stringr 1.3.1 2018-05-10 CRAN (R 3.5.0)
tibble 1.4.2 2018-01-22 CRAN (R 3.5.0)
tidyselect 0.2.4 2018-02-26 CRAN (R 3.5.0)
tools 3.5.1 2018-07-05 local
utils * 3.5.1 2018-07-05 local
whisker 0.3-2 2013-04-28 CRAN (R 3.5.0)
withr 2.1.2 2018-03-15 CRAN (R 3.5.0)
workflowr 1.1.1 2018-07-06 CRAN (R 3.5.0)
xtable 1.8-3 2018-08-29 CRAN (R 3.5.0)
yaml 2.2.0 2018-07-25 CRAN (R 3.5.0)</code></pre>
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