Last updated: 2018-05-15

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    File Version Author Date Message
    html ddf9062 LSun 2018-05-12 Update to 1.0
    rmd cc0ab83 Lei Sun 2018-05-11 update
    html 0f36d99 LSun 2017-12-21 Build site.
    html 853a484 LSun 2017-11-07 Build site.
    html 82f2a7d LSun 2017-06-02 auc
    rmd bf20fcd LSun 2017-06-02 auc
    rmd a930ad9 LSun 2017-06-02 BH
    html 7e2860d LSun 2017-06-02 auc
    rmd 549ca68 LSun 2017-06-02 auc

Introduction

We usually use AUC (area under the receiver operating characteristic curve) to measure the performance of a statistical testing procedure. In essence, AUC is solely determined by how the hypotheses are ranked by the procedure. Thus, Matthew’s intuition is that the three methods based on \(p\) values, \(p\) values, Benjamini-Hochberg, and qvalue should give the equivalent AUC. However, it doesn’t appear so in our simulation. It turns out there is a simple explanation for the difference bwteen BH and \(p\) values.

A simple illustration

Given a nominal FDR level \(\alpha\), and \(m\) \(p\) values, BH starts with the least significant or largest \(p\) value and compares each ordered \(p\) value \(p_{(k)}\) with \(\frac{\alpha}mk\). Now suppose we have 6 \(p\) values in the increasing order, \(\left\{0.005, 0.006, 0.007, 0.008, 0.009, 0.010\right\}\), plotted as follows. These \(p\) values correpond with hypotheses of true positives (“T”) or false positives (“F”). In this example, the hypotheses associated with the ordered \(p\) values are set to be \(\left\{T, T, F, F, T, F\right\}\).

Expand here to see past versions of unnamed-chunk-1-1.png:
Version Author Date
0f36d99 LSun 2017-12-21
7e2860d LSun 2017-06-02

The three dotted lines in the plot show the three scenarios with BH applied to this data set. The critical decision boundary is when we have the nominal FDR \(\alpha = 0.01\) in red. When \(\alpha < 0.01\), like the green line, no \(p\) value falls below the line and thus no discovery is declared. On the other hand, when \(\alpha > 0.01\), like the blue line, the largest \(p\) value falls below the line and thus all hypotheses would be declared as discoveries. Therefore, under BH, at different nominal FDR levels, we either fail to reject any null hypothesis, or reject all of \(6\) together. In another word, we either have false positive rate (FPR) \(=\) true positive rate (TPR) \(=\) 0, or FRP \(=\) TPR \(=\) 1. Below we plot the two ROC curves by BH and by simply thresholding \(p\) values. In this case using \(p\) values (AUC \(=\) 0.78) is actually better than using BH (AUC = 0.5).

Expand here to see past versions of unnamed-chunk-2-1.png:
Version Author Date
0f36d99 LSun 2017-12-21
7e2860d LSun 2017-06-02
  1. Note that BH indeed doesn’t change the order of hypotheses set by \(p\) values. As in this exmaple, if a hypothesis with a larger \(p\) value is rejected, all hypotheses with smaller \(p\) values will also be rejected; meanwhile, when a hypothesis with a smaller \(p\) value is not rejected, all hypotheses with larger \(p\) values won’t be rejected either.
  2. However, BH is capable of generating ties in hypotheses. As in this exmaple, all \(6\) hypothese have distinctive \(p\) values, yet they are essentially equivalent under BH.

This simple illustration shows why we would have different AUC with \(p\) values and BH.

Session information

sessionInfo()
R version 3.4.3 (2017-11-30)
Platform: x86_64-apple-darwin15.6.0 (64-bit)
Running under: macOS High Sierra 10.13.4

Matrix products: default
BLAS: /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/3.4/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] pROC_1.10.0

loaded via a namespace (and not attached):
 [1] Rcpp_0.12.16      knitr_1.20        whisker_0.3-2    
 [4] magrittr_1.5      workflowr_1.0.1   munsell_0.4.3    
 [7] colorspace_1.3-2  rlang_0.1.6       stringr_1.3.0    
[10] plyr_1.8.4        tools_3.4.3       grid_3.4.3       
[13] gtable_0.2.0      R.oo_1.21.0       git2r_0.21.0     
[16] htmltools_0.3.6   lazyeval_0.2.1    yaml_2.1.18      
[19] rprojroot_1.3-2   digest_0.6.15     tibble_1.4.1     
[22] ggplot2_2.2.1     R.utils_2.6.0     evaluate_0.10.1  
[25] rmarkdown_1.9     stringi_1.1.6     pillar_1.0.1     
[28] compiler_3.4.3    scales_0.5.0      backports_1.1.2  
[31] R.methodsS3_1.7.1

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